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Rat GAD65/67 Control Peptide

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货号：AG252

品牌：Millipore 密理博

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Description
Catalogue Number AG252
Brand Family Chemicon®
Trade Name
  • Chemicon
Description GAD, control peptide for AB1511
Overview Synthetic peptide corresponding to amino acid residues Cys+ 572-585 of rat GAD65 (Erlander et al., 1991). The amino acid sequence is wholly conserved in rat GAD67, and the peptide is located at the C-terminus in both forms of the enzyme. Sequence: [C]DFLIEEIERLGQDL.
Alternate Names
  • GAD
References
Product Information
Presentation White lyophilized powder. Soluble in water.
Applications
Key Applications
  • Cell Function Assay
Application Notes Antibody blocking (AB1511)

Optimal working dilution must be determined by the end user.
Biological Information
Purity >80%
Entrez Gene Number
Entrez Gene Summary This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome.
Gene Symbol
  • GAD2
  • MGC161607
  • GAD65
  • MGC161605
  • GAD-65
  • EC 4.1.1.15
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q05329 # Catalyzes the production of GABA.
COFACTOR: Pyridoxal phosphate.
SIZE: 585 amino acids; 65411 Da
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
PTM: Phosphorylated; which does not affect kinetic parameters or subcellular location. & Palmitoylated; which is required for presynaptic clustering.
SIMILARITY: SwissProt: Q05329 ## Belongs to the group II decarboxylase family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Long term storage at -20°C in a sealed container with desiccant for up to 12 months after date of receipt.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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