Anti-Glycogen Synthase CT, (rabbit monoclonal) - 炼石商城

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Anti-Glycogen Synthase CT, (rabbit monoclonal)

市场价：: 0.00

促销价：: ¥0.00

货号：04-357

品牌：Millipore 密理博

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北京朝阳

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₁H₈Br₂N₂O₂	62004-35-7

价格及供货情况

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Description
Overview	A potent, cell-permeable, reversible, substrate competitive, and specific inhibitor of Bruton’s Tyrosine Kinase (BTK; IC₅₀ = 17.2 µM for human BTK in vitro and IC₅₀ = 2.5 µM for recombinant BTK). Also inhibits Polo-like kinase in an ATP-competitive manner (IC₅₀ = 10 µM and 61 µM for Plx1 and Plk3, respectively), and displays antitumor properties. Does not affect the enzymatic activity of other protein tyrosine kinases, including EGFR, HCK, IRK JAK1, and JAK3 even at concentrations of 278 µM. Enhances the chemosensitivity of BTK-positive B-lineage leukemia cells to ceramide- and vincristine-induced apoptosis.
Catalogue Number	435300
Brand Family	Calbiochem®
Synonyms	α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide, BTK Inhibitor I, Bruton's Tyrosine Kinase Inhibitor I

References
References	Uckun, F.M., et al. 2006. Bioorg. Med. Chem. In press. Mahajan, S., et al. 1999. J. Biol. Chem. 274, 9587. Vassilev, A., et al. 1999. J. Biol. Chem. 274, 1646.

Product Information
CAS number	62004-35-7
ATP Competitive	Y
Form	Light brown solid
Hill Formula	C₁₁H₈Br₂N₂O₂
Chemical formula	C₁₁H₈Br₂N₂O₂
Reversible	Y
Structure formula Image

Applications

Biological Information
Primary Target	Human Bruton's Tyrosine Kinase (BTK)
Primary Target IC<sub>50</sub>	17.2 µM for human BTK in vitro and 2.5 µM for recombinant BTK
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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