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APOLIPOPROT AI, MS X HU-250UG

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货号：MAB011-A/13

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ELISA, RIA M Purified Monoclonal Antibody
Description
Catalogue Number MAB011-A/13
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Apolipoprotein A-I Antibody, clone A/13
Alternate Names
  • ApoAI
References
Product Information
Format Purified
Presentation IgG fraction purified from mouse ascites by DEAE column chromatography. In 0.015 M potassium phosphate buffer with 0.15M NaCl, 0.1% sodium azide, pH 7.2.
Applications
Application Anti-Apolipoprotein A-I Antibody, clone A/13 detects level of Apolipoprotein A-I & has been published & validated for use in ELISA, RIA.
Key Applications
  • ELISA
  • Radioimmunoassay
Application Notes Competitive RIA or EIA

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Purified human plasma Apo A-I.
Clone A/13
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Apolipoprotein A-I. No cross reactivity to Apo A-II or Apo B.

AFFINITY CONSTANT: 8 x 10E9 L/mol
Isotype IgG1
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.
Gene Symbol
  • APOA1
  • ApoA-I
  • preproapolipoprotein
  • amyloidosis
  • MGC117399
  • Apo-AI
UniProt Number
UniProt Summary FUNCTION: SwissProt: P02647 # Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).
SIZE: 267 amino acids; 30778 Da
SUBUNIT: Interacts with APOA1BP.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine.
PTM: Palmitoylated.
DISEASE: SwissProt: P02647 # Defects in APOA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). Inheritance is autosomal dominant. & Defects in APOA1 are a cause of the low HDL levels observed in high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by the absence of plasma HDL, accumulation of cholesteryl esters, premature coronary artery disease, hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. In HDLD1 patients, ApoA-I fails to associate with HDL probably because of the faulty conversion of pro-ApoA-I molecules into mature chains, either due to a defect in the converting enzyme activity or a specific structural defect in Tangier ApoA-I. & Defects in APOA1 are a cause of systemic non-neuropathic amyloidosis [MIM:105200]; also known as amyloidosis VIII or Ostertag-type amyloidosis. It is an autosomal dominant disorder characterized by generalized amyloid deposition.
SIMILARITY: SwissProt: P02647 ## Belongs to the apolipoprotein A1/A4/E family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 12 months. Do not store below -20°C or in dry ice as precipitation may occur. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 250 µg
Transport Information
Supplemental Information
Specifications

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