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Anti Scn8a (Rb Polyclonal)

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货号：AB5580-200UL

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, R ICC, IHC, WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5580-200UL
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-SCN8A Sodium Channel Antibody
Alternate Names
  • Sodium Channel Nav1.6
  • NaCh6
  • PN4
  • CerIII
Background Information Voltage-gated sodium channels perform critical roles for electrical signaling in the nervous ssystem by generating action potentials in axons and dndrites. At least 10 genes encode sodium channels in mammals, but specific physiological roles that distinguish each of these isoforms are not well known. Nav1.6 is highly concentrated at nodes of Ranvier of both sensory and motor axons in the peripheral nervous system and at nodes in the central nervous system. Because of its consistant and restrictied labeling, Anti-Nav1.6 (AB5580) has been used effectively as a nodes of Ranvier marker.
References
Product Information
Format Affinity Purified
Control
  • CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized peptide). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
Presentation Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
Applications
Application Anti-SCN8A Sodium Channel Antibody detects level of SCN8A Sodium Channel & has been published & validated for use in IC, IH & WB.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blotting
Application Notes Western blot: 3.0 μg/mL (1:200) using ECL on rat brain membranes.

Immunohistochemistry on fixed frozen sections.

Immunocytochemistry on rat dorsal root ganglion primary culture (1:100)

Dilutions should be made using a carrier protein such as BSA (1-3%)

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Peptide corresponding to amino acids 1042-1061 from mouse (Accession number AAD20438) or rat (Accession number AAC26014) Scn8a.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes Scn8a. The epitope corresponds to the intracellular loop between II and III domains of Scn8a. Does not cross react with any other known proteins.

SPECIES REACTIVITIES: It is expected that the antibody will also work on mouse and human due to sequence homology. Other species have not been tested.
Species Reactivity
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SCN8A
  • Nav1.6
  • MED
  • NaCh6
  • PN4
  • CerIII
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9UQD0 # Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
SIZE: 1980 amino acids; 225280 Da
SUBUNIT: Interacts with NEDD4 and NEDD4L (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
DOMAIN: SwissProt: Q9UQD0 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
PTM: May be ubiquitinated by NEDD4L; which would promote its endocytosis (By similarity).
SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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