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Goat Anti-4-Hydroxynonenal

市场价：: 0.00

促销价：: ¥0.00

货号：AB5605

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	ELISA, WB	Gt	Serum	Polyclonal Antibody

Description
Catalogue Number	AB5605
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-4-Hydroxynonenal Antibody
Alternate Names	4-HNE
Background Information	The peroxidation of membrane lipids by free radicals is a well-controlled, ongoing process that occurs during normal cell turnover and the normal aging process. There is also the uncontrolled process of free radical production and increased lipid peroxidation that is associated with hepatic injury as a consequence of exposure to halogenated hydrocarbons, excessive alcohol abuse, and acute or chronic iron overload. Excess free radical production and lipid peroxidation is thought to be an etiological factor in such diseases as atherosclerosis, diabetes, genetic hemochromatosis, cancer and neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.4-Hydroxynonenal (HNE) is a highly reactive, cytotoxic aldehyde that is released during the oxidation of w-6-unsaturated fatty acids. HNE can efficiently react with sulfhydryl groups or histidine and lysine groups of proteins to form stable HNE-protein adducts, in addition to phospholipids and nucleic acids. It is through this HNE-modification of biomolecules that HNE is thought to exert its cytotoxic effects. This multifunctional molecule may be considered as a "second toxic messenger," which disseminates and augments initial free radical events. It is believed to be largely responsible for the cytopathological effects observed during oxidative stress. High levels of 4-HNE have been detected in a large number of disease states, indicating some involvement of this aldehyde in their pathogenesis. Some of the prominent pathobiochemical effects of 4-HNE are its stimulation of fibrogenesis and inflammation. This indicates a potential contribution to the pathogenesis of several chronic diseases, the progression of which is supported by inflammatory reactions and characterized by fibrosis. 4-HNE may also play a role in carcinogenesis due to its ability to modulate cell proliferation through interference with the activity of cyclins and protein kinases and inhibiting the apoptotic response.

References

Product Information
Format	Serum
Presentation	Goat serum. Liquid containing 0.01% thimerosal.

Applications
Application	Anti-4-Hydroxynonenal Antibody detects level of 4-Hydroxynonenal & has been published & validated for use in ELISA & WB.
Key Applications	ELISA Western Blotting
Application Notes	Western Blot: 1:3000 on human alzheimer's Disease brain lysate. ELISA: > 1:10,000 Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	4-HNE.
Host	Goat
Specificity	Specific for 4-Hydroxynonenal (4-HNE).
Species Reactivity	Human
Species Reactivity Note	The HNE moiety recognized by this AB5605 antibody is a biochemical modification independent of species. The anit-4-HNE antibody should have wide species reactivity accordingly.
Antibody Type	Polyclonal Antibody

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.

Packaging Information
Material Size	200 µL

Transport Information

Supplemental Information

Specifications

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