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Rb X GABAA Receptor alpha1

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货号：AB5609

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R IP, WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5609
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-GABA A Receptor α1 Antibody, cytoplasmic loop
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin. Liquid in 10 mM Hepes, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. Approximate concentration is 0.15 mg/mL.
Applications
Application Anti-GABA A Receptor α1 Antibody, cytoplasmic loop is an antibody against GABA A Receptor α1 for use in IP & WB.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Application Notes Western blot: 1:1,000

Immunopreciptation: The antibody will immunoprecipitate 59% of all GABA A receptors in dodecysulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Fusion protein from the cytoplasmic loop of rat GABAA receptor alpha1 subunit.
Epitope cytoplasmic loop
Host Rabbit
Specificity GABAA receptor alpha1 subunit, cytoplasmic loop. The apparent molecular mass of 51 kDa in rat brain membrane fractions. The antibody shows no reactivity in the forebrain of alpha1 knockout mice by Western blot.
Species Reactivity
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
Gene Symbol
  • GABRA1
  • GABA
  • ECA4
  • EJM
UniProt Number
UniProt Summary FUNCTION: SwissProt: P14867 # GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SIZE: 456 amino acids; 51802 Da
SUBUNIT: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
DISEASE: SwissProt: P14867 # Defects in GABRA1 are a cause of juvenile myoclonic epilepsy (JME) [MIM:606904]. JME is a common epileptic syndrome characterized by afebrile seizures, onset in adolescence (rather than in childhood) and myoclonic jerks. & Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4) [MIM:611136]. ECA4 is a subtype of idiopathic generalized epilepsy (IGE) characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Absence seizures may either remit or persist into adulthood.
SIMILARITY: SwissProt: P14867 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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