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Rb X Calcium Sensing Receptor

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货号：AB5630P

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ELISA, WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5630P
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Ca++ Sensing Receptor Antibody
Alternate Names
  • CaSR
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA
Applications
Application This Anti-Ca++ Sensing Receptor Antibody is validated for use in ELISA, WB for the detection of Ca++ Sensing Receptor.
Key Applications
  • ELISA
  • Western Blotting
Application Notes Western blot: 1-10 μg/mL using ECL.

ELISA: 0.5-1 μg/mL using 1 μg/mL control peptide (Cat. No. AG359) per well.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen A 20 amino acid peptide sequence near the C-terminus of human CaSR. The immunogen sequence is 90% conserved in rat/mouse and 85% in bovine.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes Calcium Sensing Receptor (CaSR).
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The calcium-sensing receptor (CASR) functions as a sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, whereas mutations that activate CASR are the cause of autosomal dominant hypocalcemia. An altenatively spliced transcript variant encoding 1088 aa has been found for this gene, but its full-length nature has not been defined.
Gene Symbol
  • CASR
  • PCAR1
  • CAR
  • MGC138441
  • FIH
  • HHC1
  • NSHPT
  • HHC
  • GPRC2A
  • FHH
  • CaSR
UniProt Number
UniProt Summary FUNCTION: SwissProt: P41180 # Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.
SIZE: 1078 amino acids; 120674 Da
SUBUNIT: Interacts with VCP and RNF19A.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Found in kidney, but not in brain, lung, liver, heart, skeletal muscle, or placenta.
PTM: N-glycosylated. & Ubiquitinated by RNF19A; which induces proteasomal degradation.
DISEASE: SwissProt: P41180 # Defects in CASR are the cause of familial hypocalciuric hypercalcemia type 1 (FHH) [MIM:145980]; in which the receptor has reduced activity. FHH is characterized by altered calcium homeostasis. Affected individuals exhibit mild or modest hypercalcemia, relative hypocalciuria, and inappropriately normal PTH levels. & Defects in CASR are the cause of neonatal severe primary hyperparathyroidism (NSHPT) [MIM:239200]; in which the receptor has reduced activity. NSHPT is a rare autosomal recessive life- threatening disorder characterized by very high serum calcium concentrations, skeletal demineralization, and parathyroid hyperplasia. In some instances NSHPT has been demonstrated to be the homozygous form of FHH. & Defects in CASR are the cause of autosomal dominant hypoparathyroidism (FIH) [MIM:146200]. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps.
SIMILARITY: SwissProt: P41180 ## Belongs to the G-protein coupled receptor 3 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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