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Anti-IL-33R ST2 (IL1RL1) (rabbit polyclonal)

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货号：06-1116

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Chp, Pm WB, IH(P) Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 06-1116
Description Anti-IL-33R ST2 (IL1RL1) Antibody
Alternate Names
  • interleukin 1 receptor-like 1
  • interleukin-1 receptor-like 1
  • growth stimulation-expressed
  • homolog of mouse growth stimulation-expressed
  • interleukin 1 receptor-related protein
  • Protein ST23
Background Information Interleukin-1 receptor-like 1 (IL-33R ST2) is a member of the interleukin-1 receptor family, and is comprised of three Ig-like C2-type domains and a single TIR domain. IL-33R ST2 functions as a receptor for IL-33, and, following phosphorylation with MAPKa/ERK2, MAPK3/ERK1, MAPK8 and/ore MAPK14, serves to recruit IRAK1, IRAk4, MYD88, and TRAF6. It is also thought to have a potential role in the function of helper T-cells. High expression has been reported in colon, kidney, lung, placenta, skeletal muscle, small intestines, and the stomach. Isoform A has been noted to be more prevalent in colon, lung, placenta, testis and stomach, while Isoform B has greater presence in brain, liver and kidney.
References
Product Information
Format Affinity Purified
Control
  • Human kidney tissue lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-IL-33R ST2 (IL1RL1) Antibody is an antibody against IL-33R ST2 (IL1RL1) for use in WB, IH(P).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected IL-33R ST2 in normal human thymus tissue.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the extracellular domain of human IL-33R ST2.
Epitope Extracellular Domain
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes the extracellular domain of IL-33R ST2.
Species Reactivity
  • Human
  • Chimpanzee
  • Primate
Species Reactivity Note Demonstrated to react with human.
Predicted to react with chimpanzee and primate based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq].
Gene Symbol
  • T1
  • DER4
  • IL1RL1
  • ST2
  • FIT1
  • ST2L
  • ST2V
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

SUBUNIT STRUCTURE: Interacts with MYD88, IRAK1, IRAK4, and TRAF6.

SUBCELLULAR LOCATION: Isoform C: Cell membrane

Isoform B: Secreted Ref.10.

Cell membrane; Single-pass type I membrane protein

TISSUE SPECIFICTY: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Ref.10

SEQUENCE SIMILARITIES: Belongs to the interleukin-1 receptor family.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 TIR domain.
Molecular Weight ~30 kDa observed.
UniProtKB/Swiss-Prot Q01638 (ILRL1_HUMAN) entry describes 3 isoforms produced by alternative splicing: Isoform A at 63.358 kDa, Isoform B at 36.993 kDa, Isoform C at 29.951 kDa. The ~37 kDa product is the secreted form.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human kidney tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-33R ST2 in 10 µg of human kidney tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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