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Anti-Ataxin-1, 11NQ, clone N76/8 (mouse monoclonal)

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货号：MABN37

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R, M IHC M Purified Monoclonal Antibody
Description
Catalogue Number MABN37
Description Anti-Ataxin-1 Antibody, 11NQ, clone N76/8
Alternate Names
  • ataxin 1
  • Spinocerebellar ataxia type 1 protein
  • spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1)
  • ataxin-1
Background Information Ataxin-1 is a member of the ATXN1 protein family and contains a single AXH domain. It is a neurodegenerative disorder protein thought to have a role in the metabolism of RNA as it has been shown to localize to the RNA and transcription dependent inclusions within the nucleus. A mutation of Ataxin-1 is the cause of spinocerebellar ataxia type-1 (SCA1), a progressive, neurodegenerative disease that is autosomal dominant and primarily affects the Purjinke cells found in brain stem neuronal populations and the cerebellum. Expression of Ataxin-1 is almost ubiquitous, except in the brain where it is isolated to populations of neurons.
References
Product Information
Format Purified
Control
  • Rat hippocampus tissue
Presentation Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Ataxin-1 Antibody, 11NQ, clone N76/8 detects level of Ataxin-1 & has been published & validated for use in IH.
Key Applications
  • Immunohistochemistry
Application Notes Western Blot Analysis: A previous lot was used by an independent laboratory in rat brain tissue lysate. (James Trimmer, UC Davis/NIH NeuroMab Facility)

Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Ataxin-1 in rat cerebral cortex tissue.
Biological Information
Immunogen Linear peptide corresponding to mouse Ataxin-1.
Clone N76/8
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG2bκ
Species Reactivity
  • Rat
  • Mouse
Species Reactivity Note Demonstrated to react with rat. Predicted to react with mouse based on immunogen design.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ATXN1
  • ATX1
  • SCA1
Purification Method Protein G
UniProt Number
UniProt Summary FUNCTION: May be involved in RNA metabolism.

SUBUNIT STRUCTURE: Homooligomer By similarity. Interacts with PQBP1, UBIN and USP7 By similarity. Interacts with ANP32A. Interacts with CIC and ATXN1L. Interacts with ZNF804A (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus. Note: Colocalizes with USP7 in the nucleus (By similarity).

TISSUE SPECIFICTY: Widely expressed. In brain, the pattern of distribution is limited to neuron populations.

DEVELOPMENTAL STAGE: Transient expression burst in Purkinje cells as the cerebellar cortex becomes functional (postnatal day 14), and in mesenchymal cells of the developing intervertebral disks of the spinal column.

DOMAIN: The AXH domain is required for interaction with CIC.

PTM: Sumoylation is dependent on nuclear localization and phosphorylation at Ser-751 (By similarity).

POLYMORPHISM: The murine poly-Gln region is very limited in comparison to human ATXN1 and is not polymorphic.

SEQUENCE SIMILARITIES: Belongs to the ATXN1 family.

Contains 1 AXH domain.
Molecular Weight ~ 85 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunohistochemistry in rat hippocampus tissue.

Immunohistochemistry Analysis: 1:500 dilution of this antibody detected Ataxin-1 in rat hippocampus tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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