Anti-methyl-PP2A, C subunit, clone 2A10 (mouse monoclonal)

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Anti-methyl-PP2A, C subunit, clone 2A10 (mouse monoclonal)

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货号：04-1479

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information
Replacement Information	04-1479 is a recommended replacement for 05-546.

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, Yeast (S. cerevisiae), R, Po, Rb, Ch, Dr	WB	M	Purified	Monoclonal Antibody

Description
Catalogue Number	04-1479
Replaces	05-546
Description	Anti-methyl-PP2A Antibody, C subunit, clone 2A10
Background Information	Type 2 protein serine/threonine phosphatase (PP2A) is a trimer composed of a catalytic C subunit and two regulatory (A and B) subunits; many isoforms for the A and B subunits have been found. PP2A has a high specific activity against the α subunit of phosphorylase kinase and is insensitive to Inhibitor-2. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and by its high sensitivity to inhibition by okadaic acid. It is also thought to be the principal down-modulator of serine/threonine kinase cascades. PP2B requires Ca2+/calmodulin for activity, and is an activator of NFAT transcription factors. PP2C requires Mg2+, but is insensitive to okadaic acid, microcystin LR, or the calmodulin inhibitor trifluoperazine.

References

Product Information
Format	Purified
Control	Lysates from a yeast wild type strain (strain lacking the methyltransferase, delta PPM1) and a strain lacking the methylestrase, delta PPE1.
Presentation	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl and 0.05% sodium azide.

Applications
Application	This Anti-methyl-PP2A Antibody, C subunit, clone 2A10 is validated for use in WB for the detection of methyl-PP2A.
Key Applications	Western Blotting

Biological Information
Immunogen	KLH-conjugated, synthetic peptide (C-βA-RRTPDYFL-Ome) corresponding to amino acids 302-309 of human PP2A catalytic subunit. Clone 2A10.
Clone	2A10
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	Recognizes the methylated form of PP2A, catalytic subunit.
Isotype	IgG1κ
Species Reactivity	Human Mouse Yeast (S. cerevisiae) Rat Pig Rabbit Chicken Drosophila
Species Reactivity Note	Human, mouse and yeast. Predicted to cross react with rat, pig, rabbit, chicken and Drosophila.
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_002706.1
Modifications	Methylation
Purification Method	Protein G Purified
UniProt Number	P67775
Molecular Weight	~36 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by western blot on lysates from a yeast wild type strain (strain lacking the methyltransferase, delta PPM1) and a strain lacking the methylestrase, delta PPE1. Western Blot Analysis: 1-5 µg/mL of this antibody detected the methylated form of PP2A catalytic subunit in yeast lysates lacking the methylestrase (increased methylation). Treatment of the blot with 0.2 M NaOH will demethylate proteins, thus eliminating detection of PP2A.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Product Usage Statements

Quality Assurance

Evaluated by western blot on lysates from a yeast wild type strain (strain lacking the methyltransferase, delta PPM1) and a strain lacking the methylestrase, delta PPE1.

Western Blot Analysis: 1-5 µg/mL of this antibody detected the methylated form of PP2A catalytic subunit in yeast lysates lacking the methylestrase (increased methylation). Treatment of the blot with 0.2 M NaOH will demethylate proteins, thus eliminating detection of PP2A.

Usage Statement

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Packaging Information
Material Size	150 µg

Transport Information

Supplemental Information

Specifications

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Anti-methyl-PP2A, C subunit, clone 2A10 (mouse monoclonal)

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