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Anti-FADD (N-term), clone EP887Y, Rabbit Monoclonal

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货号：04-1113

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M WB M Purified Monoclonal Antibody
Description
Catalogue Number 05-486
Replaces 04-1113
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-FADD Antibody, clone 1F7
References
Product Information
Format Purified
Presentation PBS, pH 7.2 and 50% glycerol
Applications
Application Anti-FADD Antibody, clone 1F7 detects level of FADD & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen GST-tagged full-length fusion protein corresponding to human FADD
Clone clone 1F7
Host Mouse
Specificity FADD
Isotype IgG1
Species Reactivity
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Gene Symbol
  • FADD
  • GIG3
  • MGC8528
  • MORT1
Purification Method Protein A chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q13158 # Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
SIZE: 208 amino acids; 23279 Da
SUBUNIT: Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD.
TISSUE SPECIFICITY: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
DOMAIN:SwissProt: Q13158 Contains a death domain involved in the binding of the corresponding domain within Fas receptor.
PTM: Phosphorylated.
SIMILARITY: Contains 1 death domain. & Contains 1 DED (death effector) domain.
Molecular Weight 28kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on RIPA lysates from Jurkat cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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