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Anti-phospho-b Catenin (Ser37) (rabbit polyclonal)

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货号：07-1651

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 07-1651
Replaces 04-1070
Description Anti-phospho-β Catenin (Ser37) Antibody
Alternate Names
  • B Catenin (pSer37)
  • Beta-catenin
  • catenin (cadherin-associated protein), beta 1 (88kD)
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • catenin beta-1
Background Information Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. When β-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in β-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When β-catenin is not associated with cadherins and α-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that β-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy, HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer. After phosphorylation, beta catenin is rapidly degraded into various fragments over time (Tesco G., et al. 1998. J. Biol. Chem. 273(51):33909-33914).
References
Product Information
Format Affinity Purified
Control
  • Calycullin/Okadoic acid treated and untreated HEK293 cell lysate.
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-phospho-β Catenin (Ser37) Antibody is validated for use in WB for the detection of phospho-β Catenin (Ser37).
Key Applications
  • Western Blotting
Application Notes Western Blot Analysis: 1:500-1:1000 dilution from a representative lot detected Ser37 phosphorylated beta chain in Calyculin A/Okadoic acid treated HEK293 cell lysate.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human Phospho-B Catenin (Ser37) near the N-terminus.
Concentration Please refer to lot specific datasheet.
Host Rabbit
Species Reactivity
  • Rat
Species Reactivity Note Rat and Human. Predicted to react with Mouse, Zebrafish, Xenopus, Chicken based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • CTNNB1
  • CTNNB
Modifications
  • Phosphorylation
Purification Method Affinity Purfied
UniProt Number
Molecular Weight ~85-90 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in Calyculin A and Okadaic acid treated L6 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Ser37 phosphorylated beta chain in 10 µg of Calyculin A and Okadaic acid treated L6 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8ºC from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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