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Anti-4E-BP1 (rabbit polyclonal)

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货号：07-1416

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R, M, Po WB, IH(P) Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 07-1416
Replaces 04-321
Description Anti-4E-BP1 Antibody
References
Product Information
Format Affinity Purified
Control
  • A431 cell lysate
Presentation Purified rabbit polyclonal IgG in buffer containing Tris-citrate/phosphate, pH 7-8, and 0.1% sodium azide.
Applications
Application Anti-4E-BP1 Antibody detects level of 4E-BP1 & has been published & validated for use in WB, IH(P).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemisty (paraffin): 4E-BP1 representative staining pattern/morphology in thyroid cancer. Tissue was pretreated with citrate pH 6, antigen retrieval. A previous lot of this antibody was diluted to 1:100, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen as staining pattern/morphology in thyroid cancer tissue.

Western Blot: A previous lot of this antibody was tested on multiple lysates. See datasheet.
Biological Information
Immunogen Synthetic peptide corresponding to a portion of human eIF4E Binding Protein encoded in part by exon 2 and 3.
Host Rabbit
Specificity Eukaryotic translation initiation factor 4E binding protein (eIF4E Binding Protein, eIF4EBP1, 4E-BP1, 4EBP1).
Isotype IgG
Species Reactivity
  • Human
  • Rat
  • Mouse
  • Pig
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in sponse to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.[provided by RefSeq]
Gene Symbol
  • EIF4EBP1
  • PHAS-I
  • MGC4316
  • 4E-BP1
  • 4EBP1
  • BP-1
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.
SUBUNIT: Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs.
PTM: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the eIF4E-binding protein family.
Molecular Weight 15-20 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by Western Blot on A431 lysates.

Western Blot Analysis:
1:500-1:1,000 dilution of this lot detected 4E-BP1 on 10 μg of A431 lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 6 months at 2-8°C in undiluted aliquots from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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