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Anti-Glutamate Receptor Delta 1/2 (rabbit polyclonal)

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货号：AB2285

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, Pm, R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB2285
Description Anti-Glutamate Receptor Delta 1/2 Antibody
Alternate Names
  • GluR delta-1
  • glutamate receptor, ionotropic, delta 1
Background Information The majority of rapid excitatory transmission in the nervous system is mediated by glutamate-activated ion channels. Ionotropic glutamate receptors have been subdivided pharmacologically into AMPA (cx-amino-3-hydroxy-5methyl-Cisoxazole propionic acid), KA (kainate), and NMDA subtypes (Monaghan et al., 1989). These receptors have been implicated in a number of physiological and pathological processes. During development glutamate receptors are involved in neuronal differentiation, migration, and activity-dependent synapse formation (Balazs et al., 1989; Brewer, 1989; Komoru and Rakic, 1993). In mature neurons, long-term potentiation and long-term depression require ionotropic glutamate receptors. Glutamate-gated ion channels also play a central role in mediating the excitotoxic effects of glutamate (Olney, 1990). Pathophysiological processes thought to involve glutamate excitotoxicity and neurodegeneration include epilepsy stroke, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.
References
Product Information
Format Affinity Purified
Control
  • Rat cerebellum tissue lysate and human cerebellum tissue lysate.
Presentation Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Applications
Application Anti-Glutamate Receptor Delta 1/2 Antibody detects level of Glutamate Receptor Delta 1/2 & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Western Blotting:
Human Cerebellum Lysate.
Biological Information
Immunogen Synthetic linear peptide to the C-Terminus, conjugated to BSA.
Epitope C-Terminus, Cytoplasmic
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Cat. # AB2285 reacts with the C-Terminus of Glutamate Receptor Delta 1/2.
Species Reactivity
  • Human
  • Mouse
  • Primate
  • Rat
Species Reactivity Note Proven to react with Rat and Human. Reacts weakly with mouse. May react with Primate based on sequence homology. Reactivity with other species has not been tested.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.
Gene Symbol
  • GRID1
  • KIAA1220
  • OTTHUMP00000059648
Purification Method Antigen Affinity Purified
UniProt Number
UniProt Summary FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein by similarity. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein by similarity.

SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10) family.

Molecular Weight ~114 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Western Blotting: 1:5,000 dilution from a previous lot detected Glutamate Receptor Delta 1/2 on 10 µg of rat or human cerebellum lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8ºC from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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