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Anti-ILK, clone EPR1592, Rabbit Monoclonal

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货号：04-1149

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, H, R WB M Purified Monoclonal Antibody
Description
Catalogue Number 05-1051
Replaces 04-1149; MABT66
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-ILK Antibody, clone 6G6.3
Alternate Names
  • Integrin-Linked Kinase
  • p59
  • DKFZp686F1765
  • p59ILK
Background Information ILK (Integrin-Linked Kinase) is an intraceullar Ser/Thr kinase with four Ankyrin-like repeats. It is known to play pivotal roles in extracellular matrix mediated signaling. ILK is known to associate with β-Integrins in addition to many other focal adhesion associated proteins. In this context, ILK is involved cell adhesion/migration. The kinase activity appears to be reduced following Integrin activation, and overexpression of p59ILK inhibits cellular adhesion to Integrin substrates. Additionally, ILK has been associated with epithelial mesechymal transition (EMT) in a TGF-β1 induced Smad dependent manner (Li, 2003). Forced expression of ILK also induced the expression of MMP-2 (matrix metalloprotease 2) and promoted cell migration and invasion (Li, 2003).
References
Product Information
Format Purified
Presentation Protein G purified mouse monoclonal in storage buffer containing 0.1M Tris-Glycine, pH7.4, 15 mM NaCl, and 0.05% NaN3.
Applications
Application Anti-ILK Antibody, clone 6G6.3 detects level of ILK & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Not recommended for IP
Biological Information
Immunogen Full length recombinant GST-tagged human ILK.
Clone 6G6.3
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Recognizes ILK
Isotype IgG3κ
Species Reactivity
  • Mouse
  • Human
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Gene Symbol
  • ILK
  • p59ILK
  • ILK-1
  • P59
  • ILK1
  • ILK-2
  • ILK2
  • DKFZp686F1765
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q13418 # Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
SIZE: 452 amino acids; 51419 Da
SUBUNIT: Interacts with cytoplasmic domain of beta 1 subunit of integrin. Could also interacts with beta 2, beta 3 and/or beta 5 subunit of integrin. Interacts with LIMS1, LIMS2, parvins and probably TGFB1I1.
SUBCELLULAR LOCATION: Cell junction, focal adhesion; Cytoplasmic side.
TISSUE SPECIFICITY: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.DOMAIN:SwissProt: Q13418 A PH-like domain is involved in phosphatidylinositol phosphate binding.
PTM: Autophosphorylated on serine residues.
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 3 ANK repeats. & Contains 1 protein kinase domain.
Molecular Weight 51 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by western blot on HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at 2-8°C.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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