Anti-SAMHD1, clone GT851 (mouse monoclonal)

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Anti-SAMHD1, clone GT851 (mouse monoclonal)

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货号：MABE677

品牌：Millipore 密理博

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北京朝阳

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IHC	M	Affinity Purified	Monoclonal Antibody

Description
Catalogue Number	MABE677
Description	Anti-SAMHD1, clone GT851 Antibody
Alternate Names	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) Dendritic cell-derived IFNG-induced protein (DCIP) Monocyte protein 5 (MOP5) SAM domain and HD domain-containing protein 1 SAMHD1
Background Information	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, also known as DCIP, Dendritic cell-derived IFNG-induced protein, dNTPase, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1, is encoded by the SAMHD1 (also known as CHBL2, HDDC1, MOP5, SBBI88) gene. The sterile alpha motif domain and histidine-aspartate domain-containing protein 1 (SAMHD1) is a dGTP/GTP-activated deoxynucleotide (dNTP) triphosphohydrolase regulated by Cyclin A2/CDK1-dependent phosphorylation and is involved in balancing cellular dNTP pools. SAMHD1 was originally identified as a disease gene associated with the rare infantile encephalopathy Aicardi-Goutières syndrome. SAMHD1 was later shown to restrict HIV-1 replication in non-dividing myeloid-lineage cells and resting T cells by reducing the cellular dNTP concentration. Simian immunodeficiency viruses (SIVs) were found to use their Vpx/Vpr accessory proteins to engage and modify host Cullin-RING-type E3 ubiquitin ligases substrate recognition to target SAMHD1 for poly-ubiquitylation and subsequent proteasomal degradation.

References

Product Information
Format	Affinity Purified
Presentation	Purified mouse monoclonal containing PBS.

Applications
Application	Anti-SAMHD1, clone GT851 Antibody is an antibody against SAMHD1, clone GT851 for use in Western Blotting, Immunohistochemistry.
Key Applications	Western Blotting Immunohistochemistry
Application Notes	Immunohistochemistry Analysis (IHP): A 1:200 dilution from a representative lot detected SAMHD1 in SkHep1 xenograft tissue.

Biological Information
Immunogen	Recombinant protein corresponding to human SAMHD1.
Clone	GT851
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG2a
Species Reactivity	Human
Species Reactivity Note	Human, (H)
Antibody Type	Monoclonal Antibody
Gene Symbol	MOP5 SAMHD1
Purification Method	Protein G Purified
UniProt Number	Q9Y3Z3
Molecular Weight	~72 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in Raji, THP-1 and NCI-H929 cell lysates. Western Blotting Analysis (WB): A 1:1,000 dilution of this antibody detected SAMHD1 in Raji, THP-1 and NCI-H929 cell lysates.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Storage and Shipping Information

Storage Conditions

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.