Anti-phospho-MARCKS (Ser152/156) (rabbit polyclonal)

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Anti-phospho-MARCKS (Ser152/156) (rabbit polyclonal)

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货号：07-1238

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information
Replacement Information	07-1238 is a recommended replacement for AB5879

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R, H, M	WB, IH(P)	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	07-1238
Replaces	AB5879
Description	Anti-phospho-MARCKS (Ser152/156) Antibody
Alternate Names	Myristoylated alanine-rich C-kinase substrate Protein kinase C substrate, 80 kDa protein, light chain
Background Information	Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) is a widely expressed substrate of PKC. MARCKS is essential in neuronal development, as mice deficient in it die shortly after birth. Through its basic effector region, MARCKS associates with acidic membrane phospholipids, actin filaments, and calmodulin. Poly (ADP-ribose) also binds the basic effector region, blocking calmodulin binding, membrane association, and phosphorylation by PKC, suggesting that MARCKS may be an effector of the DNA-damage signal transduced by poly (ADP-ribose).

References

Product Information
Format	Affinity Purified
Control	A431 Cell Lysate
Presentation	Purified rabbit polyclonal IgG in 10 mM Hepes, pH 7.5, with 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.

Applications
Application	This Anti-phospho-MARCKS (Ser152/156) Antibody is validated for use in WB, IH(P) for the detection of phospho-MARCKS (Ser152/156).
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry(paraffin): Representative images from a previous lot. Optimal Staining of MARCKS With Citrate pH 6.0 Epitope Retrieval: Rat Placenta Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	Synthetic peptide corresponding to amino acids surrounding the phosphoSer152/156 of rat MARCKS.
Epitope	phosphoSer 152/156
Host	Rabbit
Specificity	MARCKS, phosphoSer152/156.
Isotype	IgG
Species Reactivity	Rat Human Mouse
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_002356.5
Entrez Gene Summary	The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
Gene Symbol	MARCKS MACS 80K-L PRKCSL FLJ14368 phosphomyristin MRACKS PKCSL FLJ90045
Modifications	Phosphorylation
Purification Method	Affinity Purfied
UniProt Number	P29966
UniProt Summary	FUNCTION: SwissProt: P29966 # MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. SIZE: 332 amino acids; 31555 Da PTM: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity. SIMILARITY: SwissProt: P29966 ## Belongs to the MARCKS family.
Molecular Weight	~80 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by Western Blot on EGF treated A431 lysates. Western Blot Analysis: 1:500 dilution of this lot detected phosphorylated MARCKS on 10 μg of EGF treated A431 lysates.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Storage and Shipping Information

Storage Conditions

Stable at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.