Anti-RSK1 (rabbit polyclonal)

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Anti-RSK1 (rabbit polyclonal)

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货号：07-1477

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R	WB, IP, ELISA	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	07-1477
Replaces	04-417
Description	Anti-Rsk1 Antibody
Alternate Names	90 kDa ribosomal protein S6 kinase 1 MAP kinase-activated protein kinase 1 Ribosomal S6 kinase 1 Ribosomal protein S6 kinase alpha-1 S6K-alpha 1 p90-RSK 1 Ribosomal protein S6 kinase alpha 1 Ribosomal protein S6 kinase, 90kD, 1 Ribosmal protein S6 kinase, 90kDa, polypeptide 1
Background Information	Rsk1, Rsk2, and Rsk3 (ribosomal protein S6 kinase, 90kDa, polypeptide 1,2,3; S6K-alpha 1,2,3) are Ser/Thr kinases which are activated by MAP Kinases, and are alternatively referred to as MAPKAP kinases 1a, 1b, and 1c. Following activation, Rsk isoforms translocate to the nucleus, where Rsk2 phosphorylates Ser10 of Histone H3, a critical step in the stimulation of immediate-early gene expression. Rsk1 is able to phosphorylate Ser133 of CREB, activating it as a transcription factor. Rsk1 activation can be monitored by phosphorylation state specific antibodies directed against sites involved in its activation.

References

Product Information
Format	Affinity Purified
Control	NIH/3T3 cell lysate
Presentation	Purified rabbit polyclonal IgG in buffer containing TBS with 0.01% Sodium Azide in 50% glycerol.

Applications
Application	Anti-Rsk1 Antibody is an antibody against Rsk1 for use in WB, IP, ELISA.
Key Applications	Western Blotting Immunoprecipitation ELISA
Application Notes	Immunoprecipitation: 4 µg of a previous lot of this antibody was used per 1500 µg of crude protein sample in Immunoprecipitation. ELISA: Recommended. Optimal working dilutions must be determined by end user. Western Blot: A previous lot of this antibody was tested on multiple lysates. See datasheet.

Biological Information
Immunogen	Synthetic peptide corresponding to the c-terminal sequence of human p90 RSK1 (C-LAQRRVRKLPSTTL).
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Recognizes p90 RSK1.
Isotype	IgG
Species Reactivity	Human Mouse Rat
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_001006665.1
Entrez Gene Summary	This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Gene Symbol	RPS6KA1 HU-1 MAPKAPK1A RSK pp90RSK1 RSK-1 p90S6K RSK1 EC 2.7.11.1
Purification Method	Affinity Purfied
UniProt Number	Q15418
UniProt Summary	FUNCTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues. SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation. PTM: Autophosphorylated on Ser-380, as part of the activation process. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. SIMILARITY: Contains 1 AGC-kinase C-terminal domain. SIMILARITY: Contains 2 protein kinase domains.
Molecular Weight	83 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by Western Blot on NIH/3T3 lysates. Western Blot Analysis: 1:500-1:1,000 dilution of this lot detected RSK1 on 10 μg of NIH/3T3 lysates.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C in undiluted aliquots from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.

Storage and Shipping Information

Storage Conditions

Stable for 1 year at -20°C in undiluted aliquots from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.