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Anti-phospho Histone H3 (Ser10), clone 63-1C-8, Recombinant

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货号：05-817R

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, DB, FC Rb Purified Monoclonal Antibody
Description
Catalogue Number 05-817R-I
Description Anti-phospho-Histone H3 (Ser10) Antibody, clone 63-1C-8, Recombinant
Alternate Names
  • H3S10P
  • Histone H3 (phospho Ser10)
  • H3 histone, family 3A
  • H3.3A
  • H3 histone, family 3B
  • H3.3B
Background Information Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming the nucleosome. Histones are modified post-translationally; and these modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. Phosphorylation at Ser10, which is linked to gene activation, prevents methylation at Lys9 but facilitates acetylation of H3 and H4. Phosphorylated Ser10 is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition, Ser10 phosphorylation is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylation at Ser10 by Aurora-B mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin.
References
Product Information
Format Purified
Presentation Purified rabbit monoclonal IgGκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-phospho-Histone H3 (Ser10) Antibody, clone 63-1C-8, is a recombinant rabbit monoclonal antibody that detects Histone H3 phosphorylated at serine 10. This purified recombinant mAb, also known as Anti-H3S10p, is published and validated in WB, Flow Cytometry, and is specificity verified by DB.
Key Applications
  • Western Blotting
  • Dot Blot
  • Flow Cytometry
Application Notes Dot Blot Specificity Analysis: AbSurance™ Histone Antibody Specificity Arrays (cat# 17-668) containing various unmodified and modified Histone peptides (see table) were probed with Anti-phospho-Histone H3 (Ser10) Antibody, clone 63-1C-8, Recombinant 0.05ug/mL.

Flow Cytometry Analysis: 0.25 µg/mL of this antibody detected Histone H3 phosphorylated at serine 10 in Jurkat T lymphocytes.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to Human Histone H3 phosphorylated at Ser10.
Epitope Phosphorylated Ser10
Clone 63-1C-8
Concentration Please refer to lot specific datasheet.
Host Rabbit
Specificity Recognizes Histone H3 phosphorylated at Serine 10.
Isotype IgGκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • HIST1H3A
  • H3FA
  • HIST1H3B
  • H3FL
  • HIST1H3C
  • H3FC
  • HIST1H3D
  • H3FB
  • HIST1H3E
  • H3FD
  • HIST1H3F
  • H3FI
  • HIST1H3G
  • H3FH
  • HIST1H3H
  • H3FK
  • HIST1H3I
  • H3FF
  • HIST1H3J
  • H3FJ
  • HIST3H3
  • H3FT
  • H3T
  • MGC126886
Modifications
  • Phosphorylation
Purification Method Protein A Purfied
UniProt Number
Molecular Weight ~ 17 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in colcemid treated HeLa cell lysate.

Western Blotting Analysis: 0.05 µg/mL of this antibody detected Histone H3 phosphorylated at serine 10 in 10 µg of colcemid treated HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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