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Anti-Serotonin Transporter (rabbit polyclonal)

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货号：AB10514P

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, H, R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB10514P
Replaces AB1594P
Description Anti-Serotonin Transporter Antibody
Alternate Names
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • sodium-dependent serotonin transporter
  • serotonin transporter
  • Solute carrier family 6 member 4
  • Na+/Cl- dependent serotonin transporter
  • 5HT transporter
  • 5-hydroxytryptamine transporter
Background Information This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
References
Product Information
Format Affinity Purified
Control
  • Western Blot : Human lung lysate.
Presentation Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Applications
Application This Anti-Serotonin Transporter Antibody is validated for use in WB for the detection of Serotonin Transporter.
Key Applications
  • Western Blotting
Biological Information
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human serotonin transporter.
Epitope Center region
Concentration 1 mg/ml
Host Rabbit
Specificity The antibody reacts with the 70 kDa serotonin transporter protein.
Species Reactivity
  • Mouse
  • Human
  • Rat
Species Reactivity Note Reacts with human, mouse and rat. Other species have not been tested. 100% homology to human, monkey, chimp, horse, mouse, rat, cow, sheep.
Antibody Type Polyclonal Antibody
Gene Symbol
  • 5-HTT
  • 5HTT
  • HTT
  • OCD1
  • SERT
  • hSERT
Purification Method Antigen Affinity Purified
UniProt Number
UniProt Summary FUNCTION: Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.

SUBUNIT STURCTURE: Interacts with TGFB1I1.

SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

POLYMORPHISM: A polymorphism in the promoter region (5-HTT gene-linked polymorphic region, 5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion involving repeat elements 6 to 8. The short allele is associated with lower transcriptional efficiency of the promoter compared with the long allele. Over half of the Caucasian population has a short allele. Individuals with one or two copies of the short allele exhibit more depressive symptoms, diagnosable depression and suicidality in relation to stressful life events than individuals homozygous for the long allele.

The polymorphism Val-425 seems to be linked to a susceptibility to obsessive-compulsive disorder (OCD) [MIM:164230].

Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism [MIM:103780].

MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

SEQUENCE SIMILARITIES: Belongs to the sodium:neurotransmitter symporter (SNF) family.
Molecular Weight 70 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Western Blot Analysis: 1:1000 dilution of this antibody detected serotonin transporter on human lung lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Store at 2-8°C for 1 year from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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