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Anti-DJ-1/PARK7 (rabbit polyclonal)

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货号：AB9718

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB9718
Replaces AB9212
Description Anti-DJ-1/PARK7 Antibody
Alternate Names
  • Oncogene DJ1
  • Parkinson disease (autosomal recessive, early onset) 7
  • Parkinson disease protein 7
  • protein DJ-1
Background Information DJ-1, also known as PARK7 (Parkinson disease (autosomal recessive, early onset) 7) is a member of the peptidase C56 family of proteins, but is not known to exhibit proteolytic activity. It acts as a positive regulator of androgen receptor-dependent transcription. It also functions as a redox-sensitive chaperone, as a sensor for oxidative stress, and it protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. DJ-1/PARK7 is characterized by onset before 40 years, slow progression and initial good response to levodopa. Defects in DJ-1/PARK7 influence susceptibility to amyotrophic lateral sclerosis-parkinsonism/ dementia complex type 2, also called Guam disease. DJ-1/PARK7 also has demonstrated cell-growth promoting activity and transforming activity. Two transcript variants encoding the same protein have been identified for this gene.
References
Product Information
Format Affinity Purified
Control
  • Human testis or murine brain tissue lysate.
Presentation Purified by peptide affinity chromatography. Supplied at 1.0 mg/ml in 100 μL of 0.1M Tris-Glycine (pH7.4) 15 mM NaCl, with 0.05% NaN3.
Applications
Application This Anti-DJ-1/PARK7 Antibody is validated for use in WB for the detection of DJ-1/PARK7.
Key Applications
  • Western Blotting
Application Notes Immunocytochemistry
Biological Information
Immunogen KLH-conjugated synthetic corresponding to a.a. 89-100 of human DJ-1/PARK7.
Epitope a.a. 89-100
Host Rabbit
Specificity Recognizes DJ-1/PARK7, Mr ~22 kDa.
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity Note Human, mouse, rat. Not tested on other species.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive
chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]
Gene Symbol
  • DJ-1
  • DJ1
  • FLJ27376
  • FLJ34360
  • FLJ92274
  • OTTHUMP00000001348
  • OTTHUMP00000001349
  • OTTHUMP00000001350
  • OTTHUMP00000001351
Purification Method Peptide affinity chromatography
UniProt Number
UniProt Summary FUNCTION:Acts as a positive regulator of androgen receptor-dependent transcription. May function as a redox-sensitiv chaperone and as a sensor for oxidative stress. Prevents aggregation of SNCA. Protects neurons against oxidative stress and cell death. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity (By similarity).
SUBUNIT: Homodimer. Binds EFCAB6/DJBP and PIAS2. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By
similarity). Note=Associated with mitochondria in some cells, particularly after oxidative stress (By similarity).
PTM:Sumoylated on Lys-130 by PIAS2 or PIAS4; which is essential for cell-growth promoting activity and transforming activity (By similarity).
SIMILARITYBelongs to the peptidase C56 family
Molecular Weight ~22 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by Western Blot Analysis
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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