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Anti-SFRP-4 (Secreted Frizzied-Related Protein-4)

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货号：09-129

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB Rb Serum Polyclonal Antibody
Description
Catalogue Number 09-129
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-SFRP4 Antibody
Alternate Names
  • secreted frizzled-related protein 4
  • FRP-4
  • sFRP-4
  • FRPHE
References
Product Information
Format Serum
Applications
Application Anti-SFRP4 Antibody detects level of SFRP4 & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Immunoblot: 1:500-1:5000 dilution is recommended depending on cell type and method of stimulation.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Recombinant full length human GST-tagged SFRP4 protein.
Host Rabbit
Specificity Recognizes SFRP4
Isotype IgG
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.
Gene Symbol
  • SFRP4
  • sFRP-4
  • FRPHE
  • frpHE
  • MGC26498
  • FRP-4
  • FrpHE
Purification Method Serum
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q6FHJ7 # Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
SIZE: 346 amino acids; 39827 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes.
DOMAIN:SwissProt: Q6FHJ7 The FZ domain is involved in binding with Wnt ligands (By similarity).
DISEASE:SwissProt: Q6FHJ7 # Associated with tumor-induced osteomalacia, a disorder in which there is an increase in renal phosphate excretion and a reduction in serum phosphate levels leading to hyperphosphaturia, hypophosphatemia and rickets.
SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP) family. & Contains 1 FZ (frizzled) domain. & Contains 1 NTR domain.
Molecular Weight 55 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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