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Anti-Calcineurin pan A (rabbit polyclonal)

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货号：07-1491

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ma WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 07-1491
Replaces AB1695
Description Anti-Calcineurin pan A Antibody
Alternate Names
  • CAM-PRP catalytic subunit
  • Calmodulin-dependent calcineurin A subunit alpha isoform
  • calcineurin A alpha
  • protein phosphatase 3 (formerly 2B), catalytic subunit,
    alpha isoform
  • protein phosphatase 3 (formerly 2B), catalytic subunit,
    alpha isoform (calcineurin A alpha)
  • protein phosphatase 3, catalytic subunit, alpha isoform
  • serine/threonine-protein phosphatase 2B catalytic subunit
    alpha isoform
Background Information Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin's multifunctional capabilities in the regulation of calcium signaling.
References
Product Information
Format Affinity Purified
Control
  • Mouse brain lysate
Presentation Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.
Applications
Application Detect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated synthetic peptide corresponding to Calcineurin.
Host Rabbit
Specificity This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species.
Species Reactivity
  • Mammals
Species Reactivity Note Reacts with human, mouse, and rat. Predicted to react with all mammals based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • CALN
  • CALNA
  • CALNA1
  • CCN1
  • CNA
  • CNA1
  • EC 3.1.3.16
  • PPP2B
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.
CATALYTIC ACTIVITY: A phosphoprotein + H2O = a protein + phosphate.
COFACTOR:Binds 1 Fe3+ ion per subunit.
Binds 1 zinc ion per subunit.
SUBUNIT STRUCTURE: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.
SUBCELLULAR LOCATION: Nucleus By similarity. Note: Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle By similarity.
SEQUENCE SIMILARITIES: Belongs to the PPP phosphatase family. PP-2B subfamily.
Molecular Weight ~58 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in Mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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