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Anti-Folr4 (Folate receptor 4), clone 5E12.2 (mouse monoclonal)

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货号：04-968

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M WB M Purified Monoclonal Antibody
Description
Catalogue Number 04-968
Description Anti-Folr4 (Folate receptor 4) Antibody, clone 5E12.2
Alternate Names
  • folate receptor 4 (delta) homolog (mouse)
  • folate receptor 4 (delta) homolog
  • Folate receptor 4
Background Information Folates are necessary and critical components in the synthesis of proteins and nucleic acids, and have putative roles in the development of both the spinal canal and brain in the early stages of pregnancy (Yamaguchi, 2007). Folate receptor 4 (Folr4) is a recently discovered cell surface receptor for folic acid on T regulatory cells (Tregs). Studies have shown that Folr4 has an integral role in the maintenance of Treg cell function (Arase, 2009). Expression of Folr4 in Tregs is notably high, making it an opportune marker for the study of Treg cells. When studied in conjunction with CD4 and CD25, Folr4 also provides researchers with a marker to distinguish between Tregs and other T cells (Chai, 2008). Tregs are of interest in therapeutic, drug research due to their ability to actively suppress immune responses.
References
Product Information
Format Purified
Control
  • Human thymus tissue lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application Anti-Folr4 (Folate receptor 4) Antibody, clone 5E12.2 detects level of Folr4 (Folate receptor 4) & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Western Blot (SNAP ID) Analysis: 1 µg/mL of this antibody detected Folate receptor 4 (Folr4) in 10 µg of human thymus tissue lysate.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human Folate receptor 4 (Folr4).
Epitope Unknown
Clone 5E12.2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes Folate receptor 4 (Folr4).
Isotype IgG1κ
Species Reactivity
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • Folbp3
  • Folr4
  • FR-delta
Purification Method Protein G Purified
UniProt Number
UniProt Summary SUBCELLULAR LOCATION: Secreted Potential.

PTM: Eight disulfide bonds are present Potential.

SEQUENCE SIMILARITIES: Belongs to the folate receptor family.
Molecular Weight ~26 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human thymus tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Folate receptor 4 (Folr4) in 10 µg of human thymus tissue lysate.
A previous lot was shown to detect Folate Receptor 4 in mouse thymus tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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