Anti-Cyclin D1, clone EPR2241(IHC)-32, Rabbit Monoclonal - 炼石商城

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Anti-Cyclin D1, clone EPR2241(IHC)-32, Rabbit Monoclonal

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货号：04-1151

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, Ht, M, R	ICC, IP, WB	M	Purified	Monoclonal Antibody

Description
Catalogue Number	05-362
Replaces	04-1151
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-Cyclin D1/2 Antibody, clone 5D4
Background Information	During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by acting as regulatory subunits of the Cdks. Early in the G1 phase of the cell cycle, cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2. Cyclin D2 is also a G1 cyclin required for G1 phase progression and is a strong candidate for a proto oncogene. Cyclin D2 can phosphorylate pRB when associated with cdk 4 and / or cdk 6.

References

Product Information
Format	Purified
Control	Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
Presentation	Protein A purified IgG2a in 50% storage buffer containing PBS, pH 7.2 and 50% glycerol.

Applications
Application	Anti-Cyclin D1/2 Antibody, clone 5D4 is a high quality Mouse Monoclonal Antibody for the detection of Cyclin D1/2 & has been validated in ICC, IP & WB.
Key Applications	Immunocytochemistry Immunoprecipitation Western Blotting

Biological Information
Immunogen	Recombinant human cyclin D1
Clone	5D4
Host	Mouse
Specificity	Recognizes p36 cyclin D1 and p34 cyclin D2; no cross-reactivity with cyclin A, B or D3.
Isotype	IgG2a
Species Reactivity	Human Hamster Mouse Rat
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_053056 NM_001759
Entrez Gene Summary	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Gene Symbol	CCND1 D11S287E U21B31 PRAD1 BCL1
Purification Method	Protein A Purfied
UniProt Number	P24385
UniProt Summary	FUNCTION: SwissProt: P24385 # Essential for the control of the cell cycle at the G1/S (start) transition. SIZE: 295 amino acids; 33729 Da SUBUNIT: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. DISEASE: SwissProt: P24385 # A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle. & A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer. & A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t(11;14)(q13;q32) with the IgH locus. SIMILARITY: SwissProt: P24385 ## Belongs to the cyclin family. Cyclin D subfamily.
Molecular Weight	34/36 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Availability by Geography	This product is not available for sale in Japan.
Quality Assurance	routinely evaluated by immunoblot on RIPA lysate from human A431 cells
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

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