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Anti-Vitamin K dependent protein S (rabbit polyclonal)

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号:AB15928

牌:Millipore 密理博

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Replacement Information

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, H, Eq, Chp, Mk, R, Rhesus Macaque WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB15928
Description Anti-Vitamin K dependent protein S Antibody
Alternate Names
  • protein S (alpha)
  • protein S, alpha
  • protein Sa
  • vitamin K-dependent plasma protein S
Background Information Vitamin K dependent protein S is an anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
References
Product Information
Format Affinity Purified
Control
  • Mouse liver tissue lysate
Presentation Purified rabbit polyclonal containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide.
Applications
Application Detect Vitamin K dependent protein S using this Anti-Vitamin K dependent protein S Antibody validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Immunoprecipitation Analysis: 1:50,000 dilution from a previous lot detected Vitamin K dependent protein S on 15 µg of normal mouse serum.
Biological Information
Immunogen This antibody is generated from rabbits immunized with a KLH-conjugated linear peptide corresponding to residues surrounding the mature peptide region of Vitamin K dependent protein S.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes Vitamin K dependent protein S.
Species Reactivity
  • Mouse
  • Human
  • Horse
  • Chimpanzee
  • Monkey
  • Rat
  • Rhesus Macaque
Species Reactivity Note Demonstrated to react with mouse. Predicted to react with human, horse and chimpanzee. Monkey (93%) and Rat (93%) Rhesus Monkey (93%).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3.
Gene Symbol
  • PROS
  • PS21
  • PS22
  • PS23
  • PS24
  • PS25
  • PSA
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Plasma.
PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.
INVOLVEMENT IN DISEASE: Defects in PROS1 are the cause of protein S deficiency (PROS1D) [MIM:612336]; also known as thrombophilia due to protein S deficiency. PROS1D is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity.
SEQUENCE SIMILARITIES: Contains 4 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 2 laminin G-like domains.
SEQUENCE CAUTION: The sequence AAP45054.1 differs from that shown. Reason: Erroneous gene model prediction.
Molecular Weight Approx. 69-75 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in mouse liver tissue lysate.
Western Blot Analysis: : 1:1000 dilution of this antibody detected Vitamin K dependent protein S on 10 µg of mouse liver tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8°C for 1 year from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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