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Anti-NR1D1 (Rev-ErbA a) (rabbit polyclonal)

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货号：AB10130

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB10130
Description Anti-NR1D1 (Rev-ErbA α) Antibody
Alternate Names
  • V-erbA-related protein EAR-1
  • nuclear receptor subfamily 1, group D, member 1
  • thyroid hormone receptor, alpha-like
Background Information Rev-ErbA alpha (NR1D1 or nuclear receptor subfamily 1, group D, member 1), is a member of the Rev-ErbA family of nuclear receptors and is a transcriptional repressor. In mammals, Rev-Erbα is highly expressed in the liver, skeletal muscle, adipose tissue, and the brain, participating in the development and circadian regulation of these tissues. Rev-Erbα regulates gene transcription by directly binding to target response elements (RevREs), comprises an A/T-rich flank followed by AGGTCA. Rev-Erbα mediates repression by recruiting the corepressor N-CoR, which then activates the histone deacetylase (HDAC) 3. A number of target genes has been identified for Rev-Erbα, including the lipoproteins ApoA1 and ApoCIII, hydratase dehydrogenase, the circadian factor BMAL, and the anti-fibrinolytic factor PAI-1. Many of these genes are coordinately regulated by Rev-erbα and the RAR-related orphan receptor RORα, which share the same response elements but exert opposite effects on gene transcription. Crosstalk between Rev-Erbα and RORα likely acts to fine-tune of their target physiologic networks, such as circadian rhythms, metabolic homeostasis, and inflammation.
References
Product Information
Format Affinity Purified
Control
  • A431 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide.
Applications
Application Anti-NR1D1 (Rev-ErbA α) Antibody is a Rabbit Polyclonal Antibody for detection of NR1D1 (Rev-ErbA α) also known as V-erbA-related protein EAR-1 & has been validated in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to residues surrounding the area near the N-terminus region of NR1D1.
Epitope Near N-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes NR1D1 near the N-terminus.
Species Reactivity
  • Human
Species Reactivity Note Proven to react with human.
Mouse and rat (92% sequence homology).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • EAR1
  • HREV
  • Rev-ErbAalpha
  • Rev-erbA-alpha
  • THRA1
  • THRAL
  • ear-1
  • hRev
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Functions as a constitutive transcriptional repressor. Possible receptor for triiodothyronine.
SUBUNIT STRUCTURE: Interacts with C1D By similarity.
SUBCELLULAR LOCATION: Nucleus Potential.
TISSUE SPECIFICITY: Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines.
DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Molecular Weight ~67 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in A431 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected NR1D1 in 10 µg of A431 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8°C for 1 year from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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