Anti-Na+/K+ ATPase a-1, clone C464.6 Alexa Fluor® 555 conjugate

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Anti-Na+/K+ ATPase a-1, clone C464.6 Alexa Fluor® 555 conjugate

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货号：05-369X-555

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
Ca, H, M, Mk, Po, R, Rb, Sh, Xn	FC, IF, WB	M	AlexaFluor®555	Monoclonal Antibody

Description
Catalogue Number	05-369X-555
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor® 555

References

Product Information
Format	AlexaFluor®555
Control	Included Negative Control: Catalog # 16-239, Alexa Fluor® 555-conjugated Normal Mouse IgG.
Presentation	25µg Alexa Fluor® 555-conjugated protein G purified mouse IgG1κ in 100µl of PBS containing 1% BSA, 0.05% Tween®-20, 0.05% sodium azide. Liquid at 4°C.

Applications
Application	Detect Na+/K+ ATPase α-1 using this Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 555 validated for use in FC, IF & WB.
Key Applications	Flow Cytometry Immunofluorescence Western Blotting

Biological Information
Immunogen	Purified Na+/K+ ATPase isolated from membrane fractions of rabbit kidney outer medulla.
Clone	C464.6
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	Specific for the α-1 subunit isoform.
Isotype	IgG1
Species Reactivity	Canine Human Mouse Monkey Pig Rat Rabbit Sheep Xenopus
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_152296.3
Entrez Gene Summary	The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.
Gene Symbol	ATP1A3 MGC13276 RDP IIIsubunit). DYT12 +K Na
Purification Method	Protein G Purified
UniProt Number	Q9N0Z6
UniProt Summary	FUNCTION: SwissProt: P13637 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. SIZE: 1013 amino acids; 111749 Da SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DISEASE: SwissProt: P13637 # Defects in ATP1A3 are the cause of dystonia-12 (DYT12) [MIM:128235]; also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant form of dystonia- parkinsonism characterized by an unusually rapid evolution of signs and symptoms. Affected persons develop dystonia and parkinsonism between 14 and 45 years of age. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability. SIMILARITY: SwissProt: P13637 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.
Molecular Weight	113 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Immunoblot Analysis: 2µg/ml of this lot detected α-1 subunit in 40μg of rat brain microsomal preparation. Immunocytochemistry: 2µg/ml of this lot showed positive immunostaining for α-1 subunit in Colo 205 cells. Flow Cytometry: 0.2μg of this lot detected α-1 subunit in fixed NCI H292 cells (see data).
Usage Statement	Alexa Fluor® is a registered trademark of Molecular Probes, Inc. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Product Usage Statements

Quality Assurance

Immunoblot Analysis: 2µg/ml of this lot detected α-1 subunit in 40μg of rat brain microsomal preparation.

Immunocytochemistry: 2µg/ml of this lot showed positive immunostaining for α-1 subunit in Colo 205 cells.

Flow Cytometry: 0.2μg of this lot detected α-1 subunit in fixed NCI H292 cells (see data).

Usage Statement

Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Do Not Freeze. Do not store the material diluted. Stable for 1 year at 4°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing cap.