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Anti-SynGAP (C-term), clone EPR2883, Rabbit Monoclonal

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货号：04-1071

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R ICC, WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 06-900
Replaces 04-1071
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-SynGAP Antibody
Background Information Silent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.
References
Product Information
Format Purified
Presentation Purified in PBS with 0.05% NaN3 and 30% Glycerol
Applications
Application Anti-SynGAP Antibody detects level of SynGAP & has been published & validated for use in IC & WB.
Key Applications
  • Immunocytochemistry
  • Western Blotting
Application Notes Immunocytochemistry: 0.1 µg/mL has been reported to immunostain SynGAP in neuron cultures fixed with 4% paraformaldehyde, 4% sucrose and perme-abilized with 0.1% Triton X-100 (2).
Biological Information
Immunogen peptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1274-1293 of rat SynGAP-a
Host Rabbit
Specificity SynGAP
Species Reactivity
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SYNGAP1
  • RASA5
  • DKFZp761G1421
  • OTTHUMP00000064825
  • SYNGAP
  • RASA1
  • KIAA1938
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q96PV0 # Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).
SIZE: 1343 amino acids; 148284 Da
SUBUNIT: Interacts CAMK2A and CAMK2B (By similarity). Interacts with MPDZ.
PTM: Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption (By similarity).
SIMILARITY: SwissProt: Q96PV0 ## Contains 1 C2 domain. & Contains 1 PH domain. & Contains 1 Ras-GAP domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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