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Anti-Endophilin-A1 (rabbit polyclonal)

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货号：ABT22

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABT22
Description Anti-Endophilin-A1 Antibody
Alternate Names
  • SH3-domain GRB2-like 2
  • bA335L15.1 (SH3-domain GRB2-like 2)
  • Endophilin A1 BAR domain
  • SH3 domain protein 2A
  • Endophilin-1
  • SH3 domain-containing GRB2-like protein 2
Background Information A member of the Endophilin family, Endophilin A1 is a protein containing SH3 domains, and has been implicated in the trafficking of clathrin-mediated synaptic vesicle endocytosis within the membrane. It was originally characterized as a presynaptically enriched protein that binds to endocytic proteins polyphosphoinositide synaptojanin and dynamin. Endophilin A1 has been implicated in endocytic vesicle budding when its function in cell-free systems and in living synapses has been disturbed. Along with the SH3 domain, Endophilin A1 contains a BAR domain in the N-terminal region, that has been found to induce and bind membrane curvature. This protein’s expression is localized to the brain, most specifically in the frontal cortex. Markedly high expression is observed in fetal cerebellum.
References
Product Information
Format Affinity Purified
Control
  • Mouse brain tissue lysate
Presentation Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide and 50% glycerol.
Applications
Application This Anti-Endophilin-A1 Antibody is validated for use in WB for the detection of Endophilin-A1.
Key Applications
  • Western Blotting
Application Notes Western Blot Analysis: 1:500 dilution from a previous lot detected Endophilin-A1 in 10 µg of rat brain and mouse brain membrane tissue lysates.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to mouse Endophilin-A1.
Epitope Unknown
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity The antibody recognizes Endophilin-A1.
Isotype IgG
Species Reactivity
  • Mouse
  • Rat
Species Reactivity Note Demonstrated to react with mouse and rat.
Human (94% sequence homology).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SH3D2A
  • CNSA2
  • EEN-B11
  • SH3P4
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.

SUBUNIT STRUCTURE: Monomer; in cytoplasm. Homodimer; when associated with membranes by similarity. Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with OPHN1 by similarity. Interacts with PDCD6IP by similarity.

SUBCELLULAR LOCATION: Cytoplasm by similarity. Membrane; Peripheral membrane protein by similarity. Note: Concentrated in presynaptic nerve terminals in neurons by similarity.

DOMAIN: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes by similarity. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.

SEQUENCE SIMILARITIES: Belongs to the endophilin family.

Contains 1 BAR domain.

Contains 1 SH3 domain.

CAUTION: Was originally (Ref.2) thought to have lysophosphatidic acid acyltransferase activity, but has since been experimentally shown not to have this activity.
Molecular Weight ~ 42 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected Endophilin-A1 in 10 µg of mouse brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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