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Anti-Ran, Polyclonal Antibody

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货号：07-517

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Xn IP, WB, ICC Rb Serum Polyclonal Antibody
Description
Catalogue Number 07-517
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Ran Antibody
References
Product Information
Format Serum
Presentation PBS and 0.1% sodium azide.
Applications
Application Anti-Ran Antibody detects level of Ran & has been published & validated for use in IP, WB & IC.
Key Applications
  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Biological Information
Immunogen His-tagged recombinant human Ran protein purified from E. coli.
Host Rabbit
Specificity Ran
Isotype IgG
Species Reactivity
  • Human
  • Xenopus
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
Gene Symbol
  • RAN
  • Gsp1
  • ARA24
  • OK/SW-cl.81
  • TC4
  • RANBP3
Purification Method Antiserum
UniProt Number
UniProt Summary FUNCTION: SwissProt: P62826 # Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
SIZE: 216 amino acids; 24423 Da
SUBUNIT: Monomer. Also forms a complex with CHC1 and interacts with the AR N-terminal poly-Gln region. The interaction with AR is inversely correlated with the poly-Gln length. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Found in a nuclear export complex with RANBP3 and XPO1. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with RANBP10. In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1. Found in a complex with HTLV-1 Rex, RANBP3 and XPO1.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Melanosome. Note=Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
TISSUE SPECIFICITY: Expressed in a variety of tissues.
PTM: The N-terminus is blocked.
SIMILARITY: SwissProt: P62826 ## Belongs to the small GTPase superfamily. Ran family.
Molecular Weight 27 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot in RIPA lysates from HeLa cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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