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Anti-Interleukin 10 Receptor Alpha (IL-10RA) (rabbit polyclonal)

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货号：06-1067

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, Chp WB, IH(P), FC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 06-1067
Description Anti-Interleukin 10 Receptor Alpha (IL-10RA) Antibody
Alternate Names
  • CDw210a antigen
  • interleukin 10 receptor, alpha
  • interleukin-10 receptor alpha chain
Background Information Interleukin 10 receptor, alpha subunit (IL-10RA or CDW210A) is a subunit for the interleukin-10 receptor and a single-pass type I membrane protein. The IL-10 receptor complex contains two subunits, the ligand binding IL10RA and the IL10RB. IL-10RA has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibit the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. IL-10RA is found in spleen, thymus, and PBMCs and is highly expressed in monocytes, B-cells, large granular lymphocytes, and T-cells. IL-10RA is weakly expressed in pancreas, skeletal muscle, brain, heart, and kidney tissues, and intermediately expressed in placenta, lung, and liver tissue.
References
Product Information
Format Affinity Purified
Control
  • Human thymus lysate
Presentation Purified rabbit polyclonal in PBS with 0.05% sodium azide.
Applications
Application This Anti-Interleukin 10 Receptor Alpha (IL-10RA) Antibody is validated for use in WB, IH(P), FC for the detection of Interleukin 10 Receptor Alpha (IL-10RA).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
  • Flow Cytometry
Application Notes Flow Cytometry Analysis: 5 µg of antibody from a previous lot detected IL-10RA in human PBMC's.

Immunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-10RA in mouse spleen tissue.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human IL-10RA.
Epitope Cytoplasmic Domain
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes the cytoplasmic domain of IL-10RA.
Species Reactivity
  • Human
  • Mouse
  • Chimpanzee
Species Reactivity Note Demonstrated to react with human and mouse.
Predicted to react with chimpanzee based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq].
Gene Symbol
  • IL10RA
  • CDW210A
  • HIL-10R
  • IL-10R-A
  • IL-10R1
  • IL10R
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Receptor for IL10; binds IL10 with a high affinity.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

TISSUE SPECIFICTY: Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.

SEQUENCE SIMLARITIES: Belongs to the type II cytokine receptor family.
Molecular Weight ~63 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human thymus lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected IL-10RA on 10 µg of human thymus lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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