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Anti-CDT1 (rabbit polyclonal)

市场价：: 0.00

促销价：: ¥0.00

货号：07-1383

品牌：Millipore 密理博

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北京朝阳

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R	WB, IP	Rb	Serum	Polyclonal Antibody

Description
Catalogue Number	07-1383
Description	Anti-CDT1 Antibody
Alternate Names	DNA replication factor Double parked homolog Double parked, Drosophila, homolog of 2 chromatin licensing and DNA replication factor 1
Background Information	CDT1 (Chromatin Licensing and DNA replication Factor 1) is an essential component of the cell cycle machinery. It plays an important role in insuring that there is only one round of DNA replication per cell cycle. CDT1 is a known substrate of Cdk2 and Cdk4 (Liu, E. 2004). It is presented in G1 of the cell cycle and is degraded as cells enter S phase (Liu, E. 2004). In higher eukaryotes, CDT1 is known to interact with Geminin, a protein that is degraded during mitosis, that inhibits it. CDT1 is marked for degradation by two E3 ligases: SCF complex and the CUL4-DDB1 complex (Sansam, 2006).

References

Product Information
Format	Serum
Presentation	Unpurified rabbit serum containing 0.05% NaN3.

Applications
Application	Detect CDT1 using this Anti-CDT1 Antibody validated for use in WB & IP.
Key Applications	Western Blotting Immunoprecipitation
Application Notes	An independent lab detected this antibody to immunoprecipitate (IP) Cdt1 using 2 μL/IP reaction (Wohlschlegel, B.T., 2000).

Biological Information
Immunogen	Recombinant protein including amino acids 238-546 of human CDT1.
Epitope	C-terminal half
Host	Rabbit
Specificity	This antibody recognizes the Cdt1.
Species Reactivity	Human Mouse Rat
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_112190.2
Gene Symbol	DUP RIS2
UniProt Number	Q9H211
UniProt Summary	FUNCTION: Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene. UniProtKB Q8R4E9 SUBUNIT STRUCTURE: Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-binding activity. UniProtKB Q8R4E9 SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases. PTM: Ubiquitinated, leading to its subsequent degradation. The interaction with GMNN protects it against ubiquitination. Phosphorylated by cyclin A-dependent kinases which results in the binding of CDT1 to the F-box protein SKP2 and subsequent degradation. Binding to GMNN is not affected by phosphorylation. SEQUENCE SIMILARITIES: Belongs to the Cdt1 family. SEQUENCE CAUTION: The sequence AF070552 differs from that shown. Reason: Frameshift at positions 278 and 312.
Molecular Weight	65 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by western blot on Jurkat cell lysate. Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect CDT1 in Jurkat cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 2 years at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

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