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Anti-phospho-CPI-17(Thr38) (rabbit polyclonal IgG)

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货号：36-006

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B, H, M, Po, R, Rb Enzyme Assays Rb Purified Polyclonal Antibody
Description
Catalogue Number 36-006
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-phospho-CPI-17 (Thr38) Antibody
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%.
Applications
Application Detect phospho-CPI-17 (Thr38) using this Anti-phospho-CPI-17 (Thr38) Antibody validated for use in EA.
Key Applications
  • Enzyme Assays
Biological Information
Immunogen Peptide corresponding to amino acids 35-46 of human CPI-17.
Host Rabbit
Specificity CPI-17 phosphorylated on Threonine 38.
Isotype IgG
Species Reactivity
  • Bovine
  • Human
  • Mouse
  • Pig
  • Rat
  • Rabbit
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase (see MIM 603768). Inhibition leads to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2+) concentration.[supplied by OMIM]
Gene Symbol
  • PPP1R14A
  • 17-KDasprotein
  • CPI-17
  • CPI17
  • PPP1INL
Modifications
  • Phosphorylation
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q96A00 # Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
SIZE: 147 amino acids; 16693 Da
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
SIMILARITY: SwissProt: Q96A00 ## Belongs to the PP1 inhibitor family.
Molecular Weight ~17 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot on phosphorylated recombinant CPI-17.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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