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Anti-cdc25A, clone DCS120 Monoclonal Antibody

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货号：05-743

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R IP, WB, IHC M Purified Monoclonal Antibody
Description
Catalogue Number 05-743
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Cdc25A Antibody, clone DCS120
References
Product Information
Format Purified
Presentation 10mM PBS, pH 7.4
Applications
Application Anti-Cdc25A Antibody, clone DCS120 is a high quality Mouse Monoclonal Antibody for the detection of Cdc25A & has been validated in IP, WB & IHC.
Key Applications
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry
Biological Information
Immunogen Purified recombinant cdc25A
Clone clone DCS120
Host Mouse
Specificity cdc25A
Isotype IgG2a
Species Reactivity
  • Human
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
Gene Symbol
  • CDC25A
  • CDC25A2
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: P30304 # Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
SIZE: 524 amino acids; 59087 Da
SUBUNIT: Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14- 3-3 epsilon when phosphorylated. Interacts with CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions with CUL1, BTRC and FBXW11 are enhanced upon DNA damage.
DOMAIN: SwissProt: P30304 The phosphodegron motif mediates interaction with specific F-box proteins when phosphorylated. Putative phosphorylation sites at Ser-79 and Ser-82 appear to be essential for this interaction.
PTM: Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser- 178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A. & Ubiquitinated. Association with the F-box proteins BTRC and FBXW11 targets the protein for ubiquitination by CUL1 and proteolysis by the ubiquitin-dependent proteasome pathway.
SIMILARITY: Belongs to the MPI phosphatase family. & Contains 1 rhodanese domain.
Molecular Weight ~65kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on nuclear extract from HeLa cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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