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Anti-Rhodopsin, clone 4D2 (mouse monoclonal)

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货号：MABN15

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R, F, M IHC, WB, ICC, ELISA M Purified Monoclonal Antibody
Description
Catalogue Number MABN15
Description Anti-Rhodopsin Antibody, clone 4D2
Alternate Names
  • rhodopsin
  • rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)
  • retinitis pigmentosa 4, autosomal dominant
  • opsin 2, rod pigment
Background Information Rhodopsin is a multi-pass, G-protein-coupled membrane receptor protein belonging to the G-protein coupled receptor 1 family. Found within rod photoreceptor cells, rhodopsin is activated by light photons in order for the visual transduction cascade to initialize. Rhodopsin is necessary to the forming of images in low light and for the viability of photoreceptor cells after birth. Mutations in rhodopsin expression are the most widely known cause of the human disease retinitis pigmentosa (RP) resulting in gradual loss of vision. At present, there are over 100 known rhodopsin mutations.
References
Product Information
Format Purified
Control
  • Rat eye tissue
Presentation Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Rhodopsin Antibody, clone 4D2 is an antibody against Rhodopsin for use in IH, WB, IC, ELISA.
Key Applications
  • Immunohistochemistry
  • Western Blotting
  • Immunocytochemistry
  • ELISA
Application Notes Western Blot Analysis: A previous lot of this antibody detected Rhodopsin by WB in goldfish retina lysate, as reported by Knight K, et al.

Immunocytochemistry: A previous lot of this antibody detected Rhodopsin by ICC in goldfish retina tissue, as reported by Knight K, et al

Immunohistochemistry Analysis: 1:500 dilution of this antibody has been shown to detect Rhodopsin in human eye tissue.

ELISA: Specificity of this antibody, from a different lot, was validated in a competitive ELISA, as reported by Laird D, et al.
Biological Information
Immunogen Rat rod outer segments corresponding to rat Rhodopsin at the N-terminus.
Epitope N-terminus
Clone 4D2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes Rhodopsin at the N-terminus.
Isotype IgG2bκ
Species Reactivity
  • Human
  • Rat
  • Fish
  • Mouse
Species Reactivity Note Demonstrated to react with human and rat. Predicted to react with mouse based on 100% sequence homology.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Visual pigment protein of rod photoreceptors involved in G-protein coupled receptor mediated signaling and phototransduction [RGD].
Gene Symbol
  • OPN2
  • RHO
  • RP4
  • CSNBAD
  • Opsin-2
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).

SUBUNIT STRUCTURE: Homodimer (By similarity).

SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note: Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia (By similarity).

TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates vision in dim light.

PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Contains one covalently linked retinal chromophore (By similarity).

SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

BIOPHYSICOCHEMICAL PROPERTIES: Absorption: Abs(max)=495 nm
Molecular Weight Expected at ~ 39 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunohistochemistry in rat eye tissue.

Immunohistochemistry Analysis: 1:500 dilution of this antibody detected Rhodopsin in rat eye tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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