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S6 Kinase Substrate Cocktail

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号:20-122

牌:Millipore 密理博

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重要规格表

Key Applications
KA
Description
Catalogue Number 20-122
Brand Family Upstate
Trade Name
  • Upstate
Description S6 Kinase Substrate Cocktail
References
Product Information
Presentation 20mM MOPS, pH 7.2, 25mM β-glycerophosphate, 5mM EGTA, 1mM sodium orthovanadate, 1mM dithiothreitol.
Applications
Key Applications
  • Kinase Assay
Application Notes For use in kinase assays.
Biological Information
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
Gene Symbol
  • RPS6KA1
  • pp90RSK1
  • HU-1
  • RSK-1
  • MAPKAPK1A
  • p90S6K
  • RSK1
  • RSK
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9UK32 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
COFACTOR: Magnesium (By similarity).
SIZE: 745 amino acids; 83872 Da
SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
PTM: Autophosphorylated on Ser-389, as part of the activation process (By similarity).
SIMILARITY: SwissProt: Q9UK32 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 1 year at -20°C
Packaging Information
Material Size 1 mL
Transport Information
Supplemental Information
Specifications

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