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Milli-Mark™ Anti-CD79acy-PE, clone HM57

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货号：FCMAB208P

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC M Phycoerythrin Monoclonal Antibody
Description
Catalogue Number FCMAB208P
Trade Name
  • Milli-Mark
Description Milli-Mark™ Anti-CD79αcy-PE Antibody, clone HM57
Alternate Names
  • B-cell antigen receptor complex-associated protein alpha chain
  • Ig-alpha
  • MB-1 membrane glycoprotein
  • Surface IgM-associated protein
  • Membrane-bound immunoglobulin-associated protein
Background Information CD79 is a disulphide-linked transmembrane heterodimer with a molecular mass of 82-95 kDa belonging to the immunoglobulin superfamily. It comprises the two glycoproteins, CD79α, with a molecular mass of 40-45 kDa, and CD79β, with a molecular mass of 37 kDa. CD79 is non-covalently associated with surface Ig, forming the B-cell receptor complex, which is required for antigen recognition. The expression of CD79 is largely restricted to B-lineage cells (Pilozzi,1998). In precursor B cells, the CD79 protein chains are already expressed in the cytoplasm (CyCD79). Surface expression of CD79 begins at the pro-B cell stage and persists throughout the B-cell differentiation. CD79α is more strongly expressed by B cells in the follicular mantle zone than by germinal centre B cells, suggesting that activation of mature B cells downregulates CD79 expression. CD79 expression ceases around the onset of plasma cell differentiation, with only a proportion of plasma cells containing CD79 (Comans-Bitter, 1997)(Nakamura, 1997). The HM57 antibody was clustered as Anti-CD79αcy at the Fifth International Workship on Human Leucocyte Differentiation Antigens (Engel, 1995).
References
Product Information
Format Phycoerythrin
Control
  • Human Lymphocytes
Presentation Purified Mouse monoclonal IgG1 conjugated to PE in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
Applications
Application Milli-Mark Anti-CD79αcy-PE Antibody, clone HM57 is an antibody against CD79αcy for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
Immunogen Synthetic peptide sequence comprising amino acids 202-216 of the CD79α protein. This oligopeptide represents an intra-cytoplasmic C-terminal part of the protein.
Clone HM57
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Antibody recognizes Human CD79αcy antigen.
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Purification Method Protein A Purfied
UniProt Number
Molecular Weight 82-95 kDa (Pilozzi,1998)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by flow cytometry using human lymphocytes
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintained refrigerated at 2-8°C from date of receipt. Protected from light in undiluted aliquots for 6 months from date of receipt.
Packaging Information
Material Size 100 tests
Transport Information
Supplemental Information
Specifications

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