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Chk X ChAT

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货号：AB15468

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M ICC, IHC Ch Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB15468
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Choline Acetyltransferase Antibody
Alternate Names
  • ChAT
References
Product Information
Format Affinity Purified
Presentation Liquid in PBS, pH 7.2 with 0.02% sodium azide.
Applications
Application Anti-Choline Acetyltransferase Antibody is an antibody against Choline Acetyltransferase for use in IC, IH.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Immunohistochemistry: 1:1,000-1:2,000 using 2% paraformaldehyde fixed tissue.

Immunocytochemistry: 1:1,000-1:2,000 using 2% paraformaldehyde fixed cells.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide corresponding to human/mouse ChAT protein.
Host Chicken
Specificity Choline acetyltransferase [ChAT]
Species Reactivity
  • Mouse
Species Reactivity Note Other species have not yet been tested. It is expected that the antibody will also react with human due to immunogen sequence similarity.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Cholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein.
Gene Symbol
  • CHAT
  • ChAT
  • CMS1A2
  • CHOACTase
  • CMS1A
  • EC 2.3.1.6
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P28329 # Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
SIZE: 748 amino acids; 82568 Da
DISEASE: SwissProt: P28329 # Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.
SIMILARITY: SwissProt: P28329 ## Belongs to the carnitine/choline acetyltransferase family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
Packaging Information
Material Size 500 µL
Transport Information
Supplemental Information
Specifications

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