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Anti-IRS-2, clone 9.5.2 (mouse monoclonal)

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货号：MABS15

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, R WB M Purified Monoclonal Antibody
Description
Catalogue Number MABS15
Replaces 06-506
Description Anti-IRS-2 Antibody, clone 9.5.2
Alternate Names
  • insulin receptor substrate 2
Background Information Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified that differ as to tissue distribution, subcellular localization, developmental expression, binding to the insulin receptor, and interaction with SH2 domain-containing proteins. In fact, IRS-1 appears to have its major role in skeletal muscle whereas IRS-2 appears to regulate hepatic insulin action as well as pancreatic beta cell development and survival. By contrast, IRS-3 and IRS-4 genes appear to play a redundant role in the IRS signaling system. Defects in muscle IRS-1 expression and function have been reported in insulin-resistant states such as obesity and type 2 diabetes.
References
Product Information
Format Purified
Control
  • Insulin treated CHO IR/IRS-2 cell lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application Anti-IRS-2 Antibody, clone 9.5.2 detects level of IRS-2 & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to mouse IRS-2.
Epitope Unknown
Clone 9.5.2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes IRS-2.
Isotype IgG1κ
Species Reactivity
  • Mouse
  • Rat
Species Reactivity Note Demonstrated to react with mouse. Predicted to react with rat based on 100% sequence homology.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • IRS2
  • IRS-2
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: May mediate the control of various cellular processes by insulin.

TISSUE SPECIFICITY: Skeletal muscle, lung, brain, liver, kidney, heart and spleen.

PTM: Phosphorylated upon DNA damage, probably by ATM or ATR by similarity.

SEQUENCE SIMILARITIES: Contains 1 IRS-type PTB domain.

Contains 1 PH domain.
Molecular Weight ~ 185 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in Insulin treated CHO IR/IRS-2 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected IRS-2 on 10 µg of Insulin treated CHO IR/IRS-2 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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