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Anti-NR3A (polyclonal antibody)

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货号：07-356

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Ma, R WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-356
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-NR3A Antibody
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Applications
Application Anti-NR3A Antibody is an antibody against NR3A for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen peptide corresponding to amino acids 1098-1113 (SRKTELEEYQKTNRTC) of rat NR3A
Host Rabbit
Specificity NR3A
Isotype IgG
Species Reactivity
  • Human
  • Mammals
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.
Gene Symbol
  • GRIN3A
  • KIAA1973
  • Glutamate
  • NMDAR-L
  • NR3A
  • FLJ45414
Purification Method Protein A chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q8TCU5 # NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).
SIZE: 1115 amino acids; 125595 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Enriched in post-synaptic plasma membrane and post-synaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity).DEVELOPMENTAL STAGE: Expressed in fetal brain.
PTM: N-glycosylated (By similarity).
SIMILARITY: SwissProt: Q8TCU5 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
Molecular Weight 130kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot in a rat brain microsomal protein preparation
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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