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Milli-Mark™ Anti-BMP-7-FITC clone 2A10

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货号：FCMAB135F

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC M FITC Monoclonal Antibody
Description
Catalogue Number FCMAB135F
Trade Name
  • Milli-Mark
Description Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10
Alternate Names
  • Bone morphogenetic protein-7
  • osteogenic protein-1
Background Information Bone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the TGF- superfamily, and is widely expressed during embryonic development. Like other members of the bone morphogenetic protein family, BMP-7 works synergistically with BMP-2 to play a key role in the differentiation of mesenchymal cells into bone and cartilage tissues by actively recruiting stem cells from the surrounding tissue, thereby initiating the bone formation cascade. In adult cells, BMP-7 is predominately expressed in the brain, kidneys, and bladder.
References
Product Information
Format FITC
Control
  • HeLa cells.
Presentation Purified mouse monoclonal IgG1κ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Applications
Application Detect BMP-7 using this Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10 validated for use in FC.
Key Applications
  • Flow Cytometry
Working Solution Cells / test Total Reaction Volume
5 μl 5 x 105 Cells / 95 μl PBS 100 μl
10 μl 1 x 106 Cells / 90 μl PBS 100 μl
Biological Information
Immunogen Recombinant full-length BMP-7 protein.
Epitope Unknown
Clone 2A10
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This monoclonal antibody recognizes BMP-7.
Isotype IgG1κ
Species Reactivity
  • Human
Species Reactivity Note Tested and passed on Human. Unconjugated antibody (MAB4350) also reacts against Mouse.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • BMP7
  • OP1
Purification Method Protein G Purified
UniProt Number
UniProt Summary Function Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Subunit structure Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 By similarity.

Subcellular location Secreted.

Tissue specificity Expressed in the kidneys and bladder. Lower levels seen in the brain.

Post-translational modification Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (Ref.5).

Pharmaceutical use Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.

Sequence similarities Belongs to the TGF-beta family.
Molecular Weight 46kDa Observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by flow cytometry using HeLa cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 tests
Transport Information
Supplemental Information
Specifications

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