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Anti-AMPK a2

市场价：: 0.00

促销价：: ¥0.00

货号：07-363

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, R	WB	Rb	Purified	Polyclonal Antibody

Description
Catalogue Number	07-363
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-AMPK α2 Antibody
Alternate Names	AMP-Activated Protein Kinase AMPK

References

Product Information
Format	Purified
Control	Rat liver preparation
Presentation	Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.

Applications
Application	Detect AMPK α2 using this Anti-AMPK α2 Antibody validated for use in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	peptide corresponding to amino acids 353-367 (C-DDSAMHIPPGLKPHP) of human AMP-Activated Protein Kinase alpha2 (AMPKalpha2) catalytic subunit
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Recognizes AMP-Activated Protein Kinase alpha2 (AMPKα2).
Isotype	IgG
Species Reactivity	Human Rat
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_006252
Entrez Gene Summary	The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Gene Symbol	PRKAA2 AMPK AMPK2 PRKAA
Purification Method	Protein A Purfied
UniProt Number	P54646
UniProt Summary	FUNCTION: SwissProt: P54646 # Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. COFACTOR: Magnesium. SIZE: 552 amino acids; 62320 Da SUBUNIT: Heterotrimer of a catalytic subunit, a beta and a gamma non-catalytic subunits. SIMILARITY: SwissProt: P54646 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. & Contains 1 protein kinase domain.
Molecular Weight	~63 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	routinely evaluated by immunoblot in a rat liver preparation
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Packaging Information
Material Size	200 µg

Transport Information

Supplemental Information

Specifications

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