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Anti-IRS1. Alexa Fluor® 488 conjugate

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货号：16-257

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R FC, ICC, IF Rb AlexaFluor®488 Polyclonal Antibody
Description
Catalogue Number 16-257
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-IRS1 Antibody, Alexa Fluor® 488 conjugate
References
Product Information
Format AlexaFluor®488
Applications
Application Detect IRS1 using this Anti-IRS1 Antibody, Alexa Fluor 488 conjugate validated for use in FC, IC & IF.
Key Applications
  • Flow Cytometry
  • Immunocytochemistry
  • Immunofluorescence
Biological Information
Immunogen c-terminal 14 amino acid peptide ([C]-ASINFQKQPEDRQ) of rat liver IRS1
Host Rabbit
Specificity IRS1
Isotype IgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • IRS1
  • IRS-1
  • HIRS-1
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
SIZE: 1242 amino acids; 131591 Da
SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7.
PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain.
Molecular Weight 165 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by flow cytometry on fixed and permeabilized HeLa cells
Usage Statement
  • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 1 year at 4°C from date of shipment
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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