Anti-SMAD3, clone EP568Y, Rabbit Monoclonal - 炼石商城

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Anti-SMAD3, clone EP568Y, Rabbit Monoclonal

市场价：: 0.00

促销价：: ¥0.00

货号：04-1035

品牌：Millipore 密理博

配送至：

北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB, ICC	M	Ascites	Monoclonal Antibody

Description
Catalogue Number	MABT521
Replaces	04-1035
Description	Anti-SMAD3, clone 5G11 Antibody
Alternate Names	Mothers against decapentaplegic homolog 3 MAD homolog 3 Mad3 Mothers against DPP homolog 3 hMAD-3 JV15-2 SMAD family member 3 SMAD 3 Smad3 hSMAD3 SMAD3
Background Information	Members of the SMAD family of signal transduction molecules are components of a critical intracellular pathway that transmits TGF-β signals from the cell surface into the nucleus. Three distinct classes of SMADs have been defined: the receptor-regulated SMADs (R-SMADs), which include Smad1, 2, 3, 5 and 8, the common-mediator SMAD (co-SMAD), SMAD4, and the antagonistic or inhibitory SMADs (I-SMADs), SMAD6 and 7. Once in the nucleus, SMADs can target a variety of DNA binding proteins to regulate transcriptional responses. Following stimulation by TGF-β, SMAD2 and SMAD3 become phosphorylated at their carboxyl termini (Ser465 and 467 on SMAD2; Ser423 and 425 on SMAD3) by TGF-β Receptor I. Phosphorylated SMAD 2/3 can complex with SMAD4, translocate to the nucleus and regulate gene expression.

References

Product Information
Format	Ascites
Presentation	Mouse monoclonal IgG1ascitic fluid containing 0.03% sodium azide.

Applications
Application	Anti-SMAD3, clone 5G11 Antibody is an antibody against SMAD3 for use in Western Blotting and Immunocytochemistry.
Key Applications	Western Blotting Immunocytochemistry
Application Notes	Immunocytochemistry Analysis (ICC): A 1:200-1,000 dilution from a representative lot detected SMAD3 in NIH/3T3 cells.

Biological Information
Immunogen	Purified recombinant fragment of human SMAD3 expressed in E. Coli.
Clone	5G11
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG1
Species Reactivity	Human Mouse
Antibody Type	Monoclonal Antibody
Gene Symbol	SMAD3 MADH3
Purification Method	Unpurified
UniProt Number	P84022
Molecular Weight	~48 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in A549 cell lysate. Western Blotting Analysis (WB): A 1:500-2,000 dilution of this antibody detected SMAD3 in A549 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

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