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Anti-Norepinephrine Transporter (rabbit polyclonal)

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货号：AB2234

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB2234
Description Anti-Norepinephrine Transporter Antibody
Alternate Names
  • Norepinephrine transporter
  • noradrenaline transporter
  • solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • solute carrier family 6 (neurotransmitter transporter, norepinephrine), member 5
  • solute carrier family 6 member 2
Background Information The SLC6A2 gene encodes a norepinephrine (noradrenaline) transporter, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. In the CNS, norepinephrine is involved in a number of physiological responses including mood, sleep regulation, alertness and arousal, both cognitive and non-cognitive expression of behaviors, and control of the endocrine and autonomic nervous systems. Peripherally, norepinephrine is present in sympathetic nerve endings and has full control of the sympathetic nervous system. Certain antidepressant medications act to raise norepinephrine, such as the SNRIs and the tricyclic antidepressants (TCAs). In essence, these medications prevent the norepinephrine transporter from serving its purpose. Norepinephrine therefore remains in the synapse longer, allowing it to reach more normal levels. Since the norepinephrine transporter is also thought to transport dopamine to some extent, SNRIs would also raise dopamine levels in the synapse.
References
Product Information
Format Purified
Control
  • PC12 lysate.
Presentation Purified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3
Applications
Application Anti-Norepinephrine Transporter Antibody detects level of Norepinephrine Transporter & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Synthetic Linear Peptide
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Cat. # AB2234 recognizes norepinephrine transporter
Species Reactivity
  • Rat
Species Reactivity Note Rat. May react with human, mouse, dog and cow based on sequence homology. Reactivity with other species has not been determined.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The SLC6A2 gene encodes a norepinephrine (noradrenaline) transporter, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis (Kim et al., 2006 [PubMed 17146058]).[supplied by OMIM]
Gene Symbol
  • NAT1
  • NET
  • NET1
  • SLC6A5
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary LOCATION: Membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family
Molecular Weight ~69 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by western blot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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