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S6 Kinase/Rsk2 Substrate Peptide 2

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货号：12-243

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 12-243
Brand Family Upstate
Trade Name
  • Upstate
Description S6 Kinase/Rsk2 Substrate Peptide 2
References
Product Information
Presentation Lyophilized powder
Applications
Application S6 Kinase/Rsk2 Substrate Peptide 2 primarily used in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
Gene Symbol
  • RPS6KA3
  • pp90RSK2
  • S6K-alpha3
  • MAPKAPK1B
  • p90-RSK2
  • CLS
  • ISPK-1
  • ISPK1
  • RSK-2
  • MRX19
  • HU-2
  • RSK2
  • RSK
  • HU-3
Protein Target Rsk2
Target Sub-Family AGC
UniProt Number
UniProt Summary FUNCTION: SwissProt: P51812 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
COFACTOR: Magnesium (By similarity).
SIZE: 740 amino acids; 83736 Da
SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
TISSUE SPECIFICITY: Expressed in many tissues, highest levels in skeletal muscle.
PTM: Autophosphorylated on Ser-386, as part of the activation process (By similarity). & Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369 (By similarity).
DISEASE: SwissProt: P51812 # Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
SIMILARITY: SwissProt: P51812 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated as a substrate for p90 Rsk-2 and p70 S6 Kinase.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Lyophilized: Stable for 2 years at -20°C
Packaging Information
Material Size 1 mg
Transport Information
Supplemental Information
Specifications

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