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IGF-1Rtide

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货号：12-527

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 12-527
Brand Family Upstate
Trade Name
  • Upstate
Description IGF-IRtide
Overview Synthetic peptide (Ac-KKKSPGEYVNIEFG-NH2) corresponding to amino acids 1-14 of Chain B of the IGF-1R. Use at 250 µM final concentration as the substrate for in vitro IGF-1R kinase assays.
References
Product Information
Presentation Lyophilized powder
Applications
Application Substrate for in vitro IGF-1R kinase assays.
Key Applications
  • Kinase Assay
Application Notes Kinase Assay: Substrate for IGF-1R (δ1-958), active (Catalog # 14-465) and Flt1, active (Catalog # 14-562).
Biological Information
Entrez Gene Number
Entrez Gene Summary This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
Gene Symbol
  • IGF1R
  • MGC142170
  • MGC142172
  • MGC18216
  • JTK13
  • IGFIR
  • CD221
Protein Target IGF-1R
Target Sub-Family TK
UniProt Number
UniProt Summary FUNCTION: SwissProt: P08069 # This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade.
SIZE: 1367 amino acids; 154793 Da
SUBUNIT: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed in a variety of tissues.
PTM: The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin- like growth factor I (IGF I). & Phosphorylation of Tyr-980 is required for IRS1- and SHC1- binding.
DISEASE: SwissProt: P08069 # Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.
SIMILARITY: SwissProt: P08069 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 3 fibronectin type-III domains. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated for use as a substrate in protein kinase assay.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Lyophilized: Stable for 2 years at -20°C from date of shipment. Rehydrated: Stable for 6 months at -20°C. Aliquot rehydrated solution to avoid repeated freezing and thawing.
Packaging Information
Material Size 1 mg
Transport Information
Supplemental Information
Specifications

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