Anti-RhoQ/TC10, clone 14G12.1 (mouse monoclonal) - 炼石商城

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Anti-RhoQ/TC10, clone 14G12.1 (mouse monoclonal)

市场价：: 0.00

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货号：MABN1589

品牌：Millipore 密理博

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北京朝阳

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	M	Culture Supernatant	Monoclonal Antibody

Description
Catalogue Number	MABN1589
Description	Anti-RhoQ/TC10 Antibody, clone 14G12.1
Alternate Names	Rho-related GTP-binding protein RhoQ Ras-like protein family member 7A Ras-like protein TC10
Background Information	Rho-related GTP-binding protein RhoQ (UniProt P17081; also known as Ras-like protein family member 7A, Ras-like protein TC10) is encoded by the RHOQ (also known as ARHQ, HEL-S-42, RASL7A, TC10) gene (Gene ID 23433) in human. Rac1, RhoA, and Cdc42 (UniProt P63000, P61586, and P60953, respectively) are among the most studied Rho family of small GTPases that are involved in a wide variety of cellular functions such as cell polarity, vesicular trafficking, and cell cycle by regulating intracellular actin dynamics. In mammals, the Rho family contains 22 members which can be further divided into the Rac subfamily (Rac1, Rac2, Rac3, and RhoG), Cdc42 subfamily (Cdc42, RhoQ/TC10, TCL, Chip, and Wrch-1), RhoA subfamlly (RhoA, RhoB, and RhoC) and other Rho-GTPases (RhoE/Rnd3, RhoH/TTF, Rif, RhoBTB1, RhoBTB2, Miro-1, Miro-2, RhoD, Rnd1, and Rnd2). RhoQ/TC10 is essential for specific types of vesicular trafficking to the plasma membrane. Studies show that RhoQ/TC10 and its effector Exo70, a component of the exocyst tethering complex, contribute to neurite outgrowth. GTP hydrolysis of RhoQ/TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.

References

Product Information
Format	Culture Supernatant
Presentation	Purified mouse monoclonal IgG2bκ antibody in supernatant without preservatives.

Applications
Application	Anti-RhoQ Antibody, clone 14G12.1 is an antibody against RhoQ/TC10 for use in Western Blotting.
Key Applications	Western Blotting

Biological Information
Immunogen	GST-tagged recombinant human RhoQ/TC10.
Clone	14G12.1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Clone 14G12.1 recognizes Rho-related GTP-binding protein RhoQ, also known as TC10
Isotype	IgG2bκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_036381
Gene Symbol	RHOQ ARHQ HEL-S-42 RASL7A TC10
UniProt Number	P17081
Molecular Weight	~27 kDa observed. 22.66 kDa calculated. Uncharacterized band(s) may appear in some lysates.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in U251 human glioma cell lysate. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected RhoQ/TC10 in 10 µg of U251 human glioma cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

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