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Ms X alpha Tubulin, Detyrosinated

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货号：MAB5566

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ma WB M Ascites Monoclonal Antibody
Description
Catalogue Number MAB5566
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Tubulin α Antibody, detyrosinated
References
Product Information
Format Ascites
Presentation Liquid. Contains no preservative.
Applications
Application This Anti-Tubulin Antibody, α, detyrosinated is validated for use in WB for the detection of Tubulin.
Key Applications
  • Western Blotting
Application Notes (add note)
Biological Information
Immunogen Synthetic peptide GEEEGE.
Epitope detyrosinated
Host Mouse
Specificity Alpha tubulin, detyrosinated.
Isotype IgG2a
Species Reactivity
  • Mammals
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.
Gene Symbol
  • TUBA1A
  • hum-a-tub2
  • LIS3
  • FLJ25113
  • TUBA3
  • B-ALPHA-1
  • hum-a-tub1
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q71U36 # Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
SIZE: 451 amino acids; 50136 Da
SUBUNIT: Dimer of alpha and beta chains.
PTM: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By similarity).
SIMILARITY: SwissProt: Q71U36 ## Belongs to the tubulin family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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